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Engineered collagen hydrogels for the sustained release of biomolecules and imaging agents: promoting the growth of human gingival cells

Title
Engineered collagen hydrogels for the sustained release of biomolecules and imaging agents: promoting the growth of human gingival cells
Author
최종훈
Keywords
engineered collagen hydrogels; biomolecules; imaging agents; sustained release; human gingival cells; growth; DIFFERENT TITANIUM SURFACES; OSTEOBLAST-LIKE CELLS; GOLD NANOPARTICLES; DRUG-DELIVERY; FACTOR-BETA; I COLLAGEN; TISSUE; FIBROBLASTS; SCAFFOLDS; CANCER
Issue Date
2014-10
Publisher
DOVE MEDICAL PRESS LTD, PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
Citation
INTERNATIONAL JOURNAL OF NANOMEDICINE, 9권, pp.5189-5201
Abstract
We present here the in vitro release profiles of either fluorescently labeled biomolecules or computed tomography contrast nanoagents from engineered collagen hydrogels under physiological conditions. The collagen constructs were designed as potential biocompatible inserts into wounded human gingiva. The collagen hydrogels were fabricated under a variety of conditions in order to optimize the release profile of biomolecules and nanoparticles for the desired duration and amount. The collagen constructs containing biomolecules/nanoconstructs were incubated under physiological conditions (ie, 37 degrees C and 5% CO2) for 24 hours, and the release profile was tuned from 20% to 70% of initially loaded materials by varying the gelation conditions of the collagen constructs. The amounts of released biomolecules and nanoparticles were quantified respectively by measuring the intensity of fluorescence and X-ray scattering. The collagen hydrogel we fabricated may serve as an efficient platform for the controlled release of biomolecules and imaging agents in human gingiva to facilitate the regeneration of oral tissues.
URI
http://dx.doi.org/10.2147/IJN.S71304http://hdl.handle.net/20.500.11754/50467
ISSN
1178-2013
DOI
10.2147/IJN.S71304
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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