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Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea

Title
Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea
Author
백승삼
Keywords
fetal anomaly; missed abortion; Coxsackievirus
Issue Date
2014-10
Publisher
연세대학교의과대학
Citation
YONSEI MEDICAL JOURNAL, 55권, 6호, pp.1562-1567
Abstract
Purpose: This study investigated the possible relationship between viral infection and first trimester pregnancy loss. Materials and Methods: A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery,and full-tem delivery at Hanyang University Hospital. Enteroviruses were detectedby semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR. Results:Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases. Conclusion:The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
URI
https://synapse.koreamed.org/DOIx.php?id=10.3349/ymj.2014.55.6.1562http://hdl.handle.net/20.500.11754/50387
ISBN
1976-2437
ISSN
0513-5796
DOI
10.3349/ymj.2014.55.6.1562
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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