Adamantane-based amphiphiles (ADAs) for membrane protein study: importance of a detergent hydrophobic group in membrane protein solubilisation

Title
Adamantane-based amphiphiles (ADAs) for membrane protein study: importance of a detergent hydrophobic group in membrane protein solubilisation
Author
채필석
Keywords
MUSCARINIC ACETYLCHOLINE-RECEPTOR; GLYCOL GNG AMPHIPHILES; AQUEOUS-SOLUTIONS; CRYSTAL-STRUCTURE; FACIAL AMPHIPHILES; COUPLED RECEPTOR; MNG AMPHIPHILES; STABILIZATION; SURFACTANTS; CRYSTALLIZATION
Issue Date
2014-10
Publisher
Royal Society of Chemistry
Citation
CHEMICAL COMMUNICATIONS, 50권, 82호, pp. 12300-12303
Abstract
We prepared adamantane-containing amphiphiles and evaluated them using a large membrane protein complex in terms of protein solubilisation and stabilization efficacy. These agents were superior to conventional detergents, especially in terms of the membrane protein solubilisation efficiency, implying a new detergent structure-property relationship.
URI
http://dx.doi.org/10.1039/c4cc05746ehttp://hdl.handle.net/20.500.11754/50373
ISBN
1364-548X
ISSN
1359-7345
DOI
10.1039/c4cc05746e
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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