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Uniform hollow-structured poly(vinyl amine) hydrogel microparticles with controlled mesh property and enhanced cell adhesion

Title
Uniform hollow-structured poly(vinyl amine) hydrogel microparticles with controlled mesh property and enhanced cell adhesion
Author
김진웅
Keywords
Hydrogel microparticles; Mesh size; Cell adhesion
Issue Date
2014-03
Publisher
Elsevier Science B.V., Amsterdam.
Citation
Polymer, Vol.55 No.5 [2014], pp. 1143-1149
Abstract
This study introduces a useful approach for fabrication of hollow-structured hydrogel microparticles and for encapsulation of biomacromolecules in the hollow core of the particles. Monodisperse hollow-structured poly(vinyl amine) hydrogel particles were fabricated without using templates that combines the dispersion polymerization and the sequential hydrolysis/crosslinking. The hydrogel shell showed pH-dependent mesh sizes; similar to 2 nm at a normal condition (pH 3-12) and similar to 11 nm at an expanded condition (pH 2). By taking advantage of pH-responsive mesh property, we demonstrated that dextran macromolecules, whose hydrodynamic radius is between the mesh sizes of the normal and expanded pH conditions, could be encapsulated and stored inside of the shell. Moreover, our hydrogel particles showed strong adhesion to human cells. Some of them were even engulfed by the cell membrane and drawn into the cell even with no aid of site-specific moieties. From these results, it is expected that the hydrogel hollow microcapsules synthesized in this study could be used for delivery of macromolecules into the cells. (C) 2014 Elsevier Ltd. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0032386114000329?via%3Dihubhttp://hdl.handle.net/20.500.11754/50334
ISSN
0032-3861
DOI
10.1016/j.polymer.2014.01.017
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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