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dc.contributor.author황승용-
dc.date.accessioned2018-03-22T02:45:00Z-
dc.date.available2018-03-22T02:45:00Z-
dc.date.issued2016-04-
dc.identifier.citationENVIRONMENTAL RESEARCH, v. 146, Page. 59-64en_US
dc.identifier.issn0013-9351-
dc.identifier.issn1096-0953-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0013935115301778?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/50326-
dc.description.abstractThe emission of volatile organic compounds (VOCs) resulting from outdoor air pollution can contribute to major public health problems. However, there has been limited research on the health effects in humans from the inhalation of VOCs. Therefore, this study conducted an in vivo analysis of the effects of toluene, one of the most commonly used chemicals in many industries, on gene expression and methylation over time using the high-throughput technique of microarray analysis. We separated participants into three groups (control, short-term exposure, and long-term exposure) to investigate the influence of toluene exposure time on gene expression. We then comprehensively analyzed and investigated the correlation between variations in gene expression and the occurrence of methylation. Twenty-six genes were upregulated and hypomethylated, while 32 genes were downregulated and hypermethylated. The pathways of these genes were confirmed to be associated with cell survival and the immune system. Based on our findings, these genes can help predict the effects of time-dependent exposure to toluene on human health. Thus, observations from our data may have implications for the identification of biomarkers of toluene exposure. (C) 2015 Published by Elsevier Inc.en_US
dc.description.sponsorshipSamples were provided by the Korea University Medical Center (IRB #AS 14039), and the microarray data analysis was carried out at BioCore Co., Ltd. (Seoul, Korea). This subject was supported by the Korea Ministry of Environment as a "Converging technology project".en_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.subjectTolueneen_US
dc.subjectTime-dependent exposureen_US
dc.subjectGene expressionen_US
dc.subjectMethylationen_US
dc.subjectMicroarrayen_US
dc.titleAssociation analysis of toluene exposure time with high-throughput mRNA expressions and methylation patterns using in vivo samplesen_US
dc.typeArticleen_US
dc.relation.volume146-
dc.identifier.doi10.1016/j.envres.2015.12.014-
dc.relation.page59-64-
dc.relation.journalENVIRONMENTAL RESEARCH-
dc.contributor.googleauthorHong, Ji Young-
dc.contributor.googleauthorYu, So Yeon-
dc.contributor.googleauthorKim, Seol Young-
dc.contributor.googleauthorAhn, Jeong Jin-
dc.contributor.googleauthorKim, Youngjoo-
dc.contributor.googleauthorKim, Gi Won-
dc.contributor.googleauthorSon, Sang Wook-
dc.contributor.googleauthorPark, Jong Tae-
dc.contributor.googleauthorHwang, Seung Yong-
dc.relation.code2016000028-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidsyhwang-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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