Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최찬범 | - |
dc.date.accessioned | 2018-03-22T02:19:28Z | - |
dc.date.available | 2018-03-22T02:19:28Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE, 2013, 28(9), Page. 1289-1292 | en_US |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2013.28.9.1289 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50313 | - |
dc.description.abstract | Activation of caspase-1 by NALP3 inflammasomes has been shown to be important in initiating acute gouty arthritis. The objectives of this study were to measure the levels of caspase-1 in synovial fluid in gout and various arthritides, and to elucidate the clinical significance of caspase-1 levels in synovial fluid. Caspase-1, IL-1β, IL-18, and uric acid were measured in synovial fluid from 112 patients with gout and other arthritides, such as rheumatoid arthritis, osteoarthritis, and spondyloarthropathy. Caspase-1 in synovial fluid from patients with crystal-induced arthritis, inflammatory arthritis, osteoarthritis, and spondyloarthropathy was 35.9 ± 86.7, 49.7 ± 107.7, 2.1 ± 7.0, and 152.6 ± 155.7 pg/mL, respectively. The mean level and the frequency of high levels (≥125 pg/mL) of caspase-1 in spondyloarthropathy were significantly higher than those in the other arthritides including gout. Caspase-1 was detectible in the synovial fluid of patients with the various arthritides. Contrary to our hypothesis, the caspase-1 level in the synovial fluid of patients with gout was not higher than in that of other arthritides. High levels of caspase-1 may be helpful in differentiating spondyloarthropathy from other arthritides. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (2010-000-0000-0328).The authors have no conflicts of interest to disclose. | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한의학회 | en_US |
dc.subject | Caspase-1 | en_US |
dc.subject | Synovial Fluid | en_US |
dc.subject | Gout | en_US |
dc.subject | Spondyloarthropathies | en_US |
dc.title | Caspase-1 Level in Synovial Fluid Is High in Patients with Spondyloarthropathy but Not in Patients with Gout | en_US |
dc.type | Article | en_US |
dc.relation.no | 9 | - |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.3346/jkms.2013.28.9.1289 | - |
dc.relation.page | 1289-1292 | - |
dc.relation.journal | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.contributor.googleauthor | Son, Chang-Nam | - |
dc.contributor.googleauthor | Bang, So-Young | - |
dc.contributor.googleauthor | Kim, Ji-Hae | - |
dc.contributor.googleauthor | Choi, Chan-Bum | - |
dc.contributor.googleauthor | Jun, Jae-Bum | - |
dc.contributor.googleauthor | Kim, Tae-Hwan | - |
dc.relation.code | 2013010765 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | cbchoi | - |
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