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dc.contributor.author민경환-
dc.date.accessioned2018-03-21T08:07:31Z-
dc.date.available2018-03-21T08:07:31Z-
dc.date.issued2012-09-
dc.identifier.citationJapanese Journal of Infectious Diseases, 2012, 65(3), P.193-197en_US
dc.identifier.issn1344-6304-
dc.identifier.urihttps://www.jstage.jst.go.jp/article/yoken/65/3/65_193/_article-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/50177-
dc.description.abstractThe first large-scale outbreaks of respiratory disease in the 21st century were caused by the influenza A (H1N1) virus in 2009, which affected mostly young adults. The M59 vaccine was developed to control pandemic influenza A (H1N1). However, the complications arising from the use of the non-adjuvanted and adjuvanted vaccines in young male Korean soldiers have not previously been evaluated and compared. We conducted a prospective multicenter study of 2,864 healthy male soldiers aged 19 to 25 years to evaluate the adverse events associated with both the MF59-adjuvanted and non-adjuvanted forms of the influenza A/California/2009 (H1N1) surface-antigen vaccine. In most cases, the adverse-event symptoms were mild, and the most frequent adverse events were swelling at the injection site and myalgia, which were noted in 4.8% and 10.7% of participants, respectively. Administration of the MF59-adjuvanted vaccine was associated with an increased incidence of local (crude odds ratio [cOR], 1.56; 95% confidence interval [CI], 1.11-2.29) and systemic adverse events (cOR, 1.64; 95% CI, 1.29-2.07) after vaccination. Atopic dermatitis (adjusted OR [aOR], 2.32; 95% CI, 0.99-5.46) might be the choice risk factor for local adverse events, and adjuvant use (aOR, 1.35; 95% CI, 1.03-1.78) was a significant predictor of systemic adverse events in healthy young male Korean soldiers.en_US
dc.language.isoenen_US
dc.publisherInstitute of Infectious Diseasesen_US
dc.subjectINFLUENZA-VIRUSen_US
dc.subjectIMMUNOGENICITYen_US
dc.subjectSAFETYen_US
dc.subjectINFECTIONen_US
dc.subjectMF59; DIPHTHERIAen_US
dc.subjectRESPONSESen_US
dc.subjectCHILDRENen_US
dc.subjectANTIBODYen_US
dc.subjectTETANUSen_US
dc.titleComparison of the adverse events associated with MF59-adjuvanted and non-adjuvanted H1N1 vaccines in healthy young male Korean soldiersen_US
dc.typeArticleen_US
dc.identifier.doi10.7883/yoken.65.193-
dc.relation.journalJAPANESE JOURNAL OF INFECTIOUS DISEASES-
dc.contributor.googleauthorHwang, Se-Min-
dc.contributor.googleauthorKim, Hack-Lyoung-
dc.contributor.googleauthorMin, Kyueng-Whan-
dc.contributor.googleauthorKim, Min-
dc.contributor.googleauthorLim, Jae-Sung-
dc.contributor.googleauthorChoi, Jin-Man-
dc.contributor.googleauthorChun, Byung-Chul-
dc.contributor.googleauthorKim, Min-Jeong-
dc.contributor.googleauthorLee, Sang-Min-
dc.contributor.googleauthorKim, Seung-Young-
dc.relation.code2012204511-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkyueng-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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