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dc.contributor.author남태규-
dc.date.accessioned2018-03-21T08:06:39Z-
dc.date.available2018-03-21T08:06:39Z-
dc.date.issued2016-03-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH, v. 39, No. 3, Page. 302-309en_US
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://link.springer.com/article/10.1007/s12272-016-0706-z-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/50176-
dc.description.abstractSynthesis of indazolone derivatives, which exhibit diverse biological and pharmaceutical activities, were achieved by hypervalent lambda(5) iodine reagents, such as iodoxybenzoic acid (IBX),-mediated oxidative N-N bond forming cyclization. In this study, the equivalence of IBX was optimized to promote the formation of N-N bond by oxidatively generated acylnitrenium ion. Dimethoxyethane and dichloroethane were discovered as alternative solvents and the reaction could be conducted in more concentrated condition. Some unprecedented substrates successfully afforded the corresponding indazolone in new condition discovered in this study. When the reactions were conducted in DME solvent, substrates with no electron-rich phenyl substituted amides afforded the unanticipated quinazolin-4-ones in moderate yields, which were not formed in DCE solvent. The formation of quinazolin-4-ones was attributed to the in situ generation of formaldehyde from DME. Therefore, the reaction might undergo different pathway in DME when the substrate aryl amides have phenyl rings without electron donating substituents.en_US
dc.description.sponsorshipThis work was supported by Research Fund of Hanyang University (HY-2012-N).en_US
dc.language.isoen_USen_US
dc.publisherPHARMACEUTICAL SOC KOREAen_US
dc.subjectHypervalent iodineen_US
dc.subjectIndazoloneen_US
dc.subjectN-N bond formationen_US
dc.subjectIodoxybenzoic aciden_US
dc.subjectQuinazolin-4-oneen_US
dc.titleIBX-mediated synthesis of indazolone via oxidative N-N bond formation and unexpected formation of quinazolin-4-one: in situ generation of formaldehyde from dimethoxyethaneen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume39-
dc.identifier.doi10.1007/s12272-016-0706-z-
dc.relation.page302-309-
dc.relation.journalARCHIVES OF PHARMACAL RESEARCH-
dc.contributor.googleauthorPark, Sang Won-
dc.contributor.googleauthorChoi, Hoon-
dc.contributor.googleauthorLee, Jung-hun-
dc.contributor.googleauthorLee, Yeon-Ju-
dc.contributor.googleauthorKu, Jin-Mo-
dc.contributor.googleauthorLee, Sang Yeul-
dc.contributor.googleauthorNam, Tae-gyu-
dc.relation.code2016007276-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidtnam-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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