Fatal Varicella-Zoster Virus Vasculopathy Associated With Adalimumab Therapy
- Title
- Fatal Varicella-Zoster Virus Vasculopathy Associated With Adalimumab Therapy
- Author
- 김현영
- Keywords
- Aged; Antibodies; Monoclonal; Humanized; adverse effects; therapeutic use; Antirheumatic Agents; Arthritis; Rheumatoid; drug therapy; Encephalitis; Varicella Zoster; chemically induced; virology; Fatal Outcome; Female; Herpesvirus 3; Human; Humans; Vasculitis; Central Nervous System
- Issue Date
- 2012-09
- Publisher
- American Medical Association
- Citation
- Archives of Neurology, Sep 2012, Nol.69,No.9, P.1193-1196
- Abstract
- OBJECTIVE: To describe the case of a patient who had been receiving adalimumab for rheumatoid arthritis and died of varicella-zoster virus vasculopathy with multifocal cerebral hemorrhage. DESIGN: Case report. SETTING: Hanyang University Hospital, Seoul, Republic of Korea. PATIENT: A 66-year-old woman with adalimumab therapy for rheumatoid arthritis followed by stuporous mental changes. RESULTS: Magnetic resonance imaging scans showed multifocal parenchymal lesions and hemorrhage in the brainstem and supratentorial areas. Polymerase chain reaction analysis of the cerebrospinal fluid was positive for varicella-zoster virus. The patient died of multifocal vasculopathy despite intensive antiviral and antibacterial medication. CONCLUSIONS: Varicella-zoster virus multifocal vasculopathy with encephalitis may be associated with adalimumab therapy. Clinicians should be aware of the possibility of fatal varicella-zoster virus vasculopathy with encephalitis in patients undergoing adalimumab therapy for rheumatoid arthritis.
- URI
- http://jamanetwork.com.ssl.access.hanyang.ac.kr/journals/jamaneurology/fullarticle/1190811http://hdl.handle.net/20.500.11754/50116
- ISSN
- 0003-9942
- DOI
- 10.1001/archneurol.2011.3741
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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