33 0

Influence of hydrophilic polymers on functional properties and wound healing efficacy of hydrocolloid based wound dressings

Title
Influence of hydrophilic polymers on functional properties and wound healing efficacy of hydrocolloid based wound dressings
Author
김진기
Keywords
Sodium alginate; Hydrocolloid wound dressing; Hydrophilic polymers; Bioadhesive force; Mechanical properties; Healing efficacy
Issue Date
2016-03
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 501, No. 1-2, Page. 160-166
Abstract
The purpose of this study was to investigate the influence of different hydrophilic polymers on the swelling, bioadhesion and mechanical strength of hydrocolloid wound dressings (HCDs) in order to provide an appropriate composition for a hydrocolloid wound dressing system. In this study, the HCDs were prepared with styrene-isoprene-styrene copolymer (SIS) and polyisobutylene (PIB) as the base using a hot melting method. Additionally, numerous SIS/PIB-based HCDs were prepared with six hydrophilic polymers, and their wound dressing properties were assessed. Finally, the wound healing efficacy of the selected formulations was compared to a commercial wound dressing. The swelling ratio, bioadhesive force and mechanical strengths of HCDs were increased in the order of sodium alginate ˃ sodium CMC = poloxamer = HPMC ˃ PVA = PVP, sodium alginate ˃ sodium CMC = poloxamer ˃ PVA˃ HPMC = PVP and sodium alginate ˃= PVA ˃ PVP = HPMC = sodium CMC ˃ poloxamer, respectively. Among the hydrophilic polymers tested, sodium alginate most enhanced the swelling capacity, bioadhesive force and mechanical strengths. Thus, the hydrophilic polymers played great role in the swelling, bioadhesion and mechanical strength of SIS/PIB-based HCDs. The HCD formulation composed of PIB, SIS, liquid paraffin and sodium alginate at the weight ratio of 20/25/12/43 gave better wound dressing properties and more excellent wound healing efficacy than the commercial wound dressing. Therefore, the novel HCD formulation could be a promising hydrocolloid system for wound dressings. (C) 2016 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0378517316300448http://hdl.handle.net/20.500.11754/49999
ISSN
0378-5173; 1873-3476
DOI
10.1016/j.ijpharm.2016.01.044
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE