Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이오영 | - |
dc.date.accessioned | 2018-03-21T02:43:50Z | - |
dc.date.available | 2018-03-21T02:43:50Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.citation | Liver International, 2013, 33(4), p.535-543 | en_US |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1111/liv.12110/abstract?systemMessage=Wiley+Online+Library+is+migrating+to+a+new+platform+powered+by+Atypon%2C+the+leading+provider+of+scholarly+publishing+platforms.+The+new+Wiley+Online+Library+will+be+migrated+over+the+weekend+of+March+17+and+18.You+should+not+experience+any+issues+or+loss+of+access+during+this+time.+For+more+information%2C+please+visit+our+migration+page%3A++http%3A%2F%2Fwww.wileyactual.com%2FWOLMigration%2F | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/49932 | - |
dc.description.abstract | Background 5-hydroxytryptamine (5- HT) receptors are upregulated in activated hepatic stellate cells ( HSCs), and are therefore thought to play an important role in their activation. Aim The aim of this study was to determine whether 5- HT2A receptor antagonists affect the activation or apoptosis of HSCs in vitro and/or in vivo. Methods For the in vitro experiments, the viability, apoptosis and wound healing ability of LX-2 cells were examined after treatment with various 5- HT2A receptor antagonists. Levels of HSC activation markers (procollagen type I, α- SMA, TGF-β and Smad 2/3) were measured. For in vivo experiments, rats were divided into three groups: (i) a control group, (ii) a disease group, in which cirrhosis was induced by thioacetamide (iii) a treatment group, in which cirrhosis was induced and a 5- HT2A receptor antagonist (sarpogrelate, 30 mg/kg) was administered. Results 5-HT2A, but not 5-HT2B receptor mRNA increased with time upon HSC activation. 5-HT2A receptor antagonists (ketanserin and sarpogrelate) inhibited viability and wound healing in LX-2 cells and induced apoptosis. Expression of α-SMA and procollagen type I was also inhibited. In the in vivo study, lobular inflammation was reduced in the sarpogrelate-treated group, but there was only slight and statistically insignificant attenuation of periportal fibrosis. Expression of α-SMA, TGF-β and Smad 2/3 was also reduced in the treatment group. Conclusions 5- HT2A receptor antagonists can reduce inflammation and the activation of HSCs in this cirrhotic model. | en_US |
dc.language.iso | en | en_US |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject | 5-HT | en_US |
dc.subject | 5-HT2A receptor | en_US |
dc.subject | fibrosis | en_US |
dc.subject | hepatic stellate cell | en_US |
dc.subject | sarpogrelate | en_US |
dc.title | 5-HT2A receptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 33 | - |
dc.identifier.doi | 10.1111/liv.12110 | - |
dc.relation.page | 535-543 | - |
dc.relation.journal | LIVER INTERNATIONAL | - |
dc.contributor.googleauthor | Kim, Dong-Chan | - |
dc.contributor.googleauthor | Jun, Dae-Won | - |
dc.contributor.googleauthor | Kwon, Young-Il | - |
dc.contributor.googleauthor | Lee, Kang-Nyeong | - |
dc.contributor.googleauthor | Lee, Hang-Lak | - |
dc.contributor.googleauthor | Lee, Oh-Young | - |
dc.contributor.googleauthor | Yoon, Byung-Chul | - |
dc.contributor.googleauthor | Choi, Ho-Soon | - |
dc.contributor.googleauthor | Kim, Eun-Kyung | - |
dc.relation.code | 2013011164 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | leeoy | - |
dc.identifier.researcherID | 24477520300 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.