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Functional analysis of endocrine disruptor pesticides affected transcriptome and microRNA regulation in human hepatoma cell line

Title
Functional analysis of endocrine disruptor pesticides affected transcriptome and microRNA regulation in human hepatoma cell line
Author
황승용
Keywords
Endocrine disruptor pesticides; Endocrine disrupting chemical; Pesticide; MicroRNA; Biological process
Issue Date
2014-12
Publisher
THE KOREAN SOCIETY OF TOXICOGENOMICS AND TOXICOPRPTEOMICS
Citation
MOLECULAR AND CELLULAR TOXICOLOGY, 2014, 4(10), P.393-400
Abstract
Endocrine disrupting chemicals (EDCs) alter the normal endocrine system of wildlife and humans. Among pesticides, a large number of chemicals have been identified as endocrine disruptors. Pesticides are designed to be toxic to pests and vectors of disease; however, human beings can easily be exposed to these chemicals because they are present in the environment at very low levels. In the present study, we examined the adverse effects of endocrine disrupting chemicals by screening transcripts and microRNAs. microRNAs are known as regulators of many protein coding genes. Therefore, the microRNAs regulating mRNAs were analyzed, including functional analysis. In addition, we tried to compare two types of chemicals, endocrine disruptor pesticides and EDCs. Endocrine disruptor pesticides were found to affect the reproductive or development systems by altering the Wnt signaling pathway, similar to EDCs. On the other hand, the genes involved in axon guidance and ubiquitin-mediated proteolysis were differentially regulated by treatment with endocrine disruptor pesticides compared with EDCs.
URI
http://link.springer.com/article/10.1007%2Fs13273-014-0044-5http://hdl.handle.net/20.500.11754/49757
ISSN
1738-642X
DOI
10.1007/s13273-014-0044-5
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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