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dc.contributor.author최준호-
dc.date.accessioned2018-03-20T06:44:05Z-
dc.date.available2018-03-20T06:44:05Z-
dc.date.issued2014-12-
dc.identifier.citationNeuro Report, 2014, 26(17), P.1399-1404en_US
dc.identifier.issn0959-4965-
dc.identifier.urihttps://journals.lww.com/neuroreport/Abstract/2014/12030/Fluoxetine_induced_regulation_of_heat_shock.12.aspx-
dc.description.abstractFluoxetine, a serotonin-selective reuptake inhibitor, exerts antidepressant and antianxiety effects on major depressive and anxiety disorders. Previous studies suggest that treatment with fluoxetine influences the expression of various proteins that are involved in proliferation, differentiation, and apoptosis in the neuronal cells of the brain. However, many aspects of the molecular pathways that modulate antidepressant action are not well understood. Here, with the aim of identifying proteins involved in antidepressant action, we examined the protein expression profile of human embryonic carcinoma (NCCIT) cells in response to fluoxetine treatment using proteomic techniques such as two-dimensional gel electrophoresis and matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS). We found several upregulated and downregulated proteins in fluoxetine-treated NCCIT cells, and then biochemically confirmed the increased expression of heat shock protein 90 and 14-3-3[epsilon], which play an essential role in many cellular mechanisms including cell cycle control and other signaling pathways. Our data suggest that the regulated expression of heat shock protein 90, 14-3-3[epsilon], and other identified proteins may be associated with the therapeutic action of fluoxetine.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2007-N) to J.Cen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.subjectantidepressive agentsen_US
dc.subjectcell lineen_US
dc.subjectmolecular chaperonesen_US
dc.subjectproteomicsen_US
dc.titleFluoxetine-induced regulation of heat shock protein 90 and 14-3-3 epsilon in human embryonic carcinoma cellsen_US
dc.typeArticleen_US
dc.relation.no17-
dc.relation.volume25-
dc.identifier.doi10.1097/WNR.0000000000000284-
dc.relation.page1399-1404-
dc.relation.journalNEUROREPORT-
dc.contributor.googleauthorChai, Young Gyu-
dc.contributor.googleauthorOh, Daeyoung-
dc.contributor.googleauthorChoi, Mi Ran Choi-
dc.contributor.googleauthorHan, Dal Mu Ri-
dc.contributor.googleauthorChoi, Joonho-
dc.relation.code2014036652-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjchoi-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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