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In vitro generation of mature dopamine neurons by decreasing and delaying the expression of exogenous Nurr1

Title
In vitro generation of mature dopamine neurons by decreasing and delaying the expression of exogenous Nurr1
Author
임미선
Keywords
Parkinson's disease; Dopamine neurons; Nurr1; Neuronal maturation; Doxycycline inducible expression system
Issue Date
2012-04
Publisher
Company of Biologists Ltd
Citation
Development (Cambridge), 2012, 139(13), P.2447-2451
Abstract
Neural stem/progenitor cell (NSC/NPC) cultures can be a source of dopamine (DA) neurons for experimental and transplantation purposes. Nurr1, a steroid receptor transcription factor, can overcome the limitations associated with differentiation of cultured NPCs into DA neurons. However, forced Nurr1 expression in NPC cultures generates non-neuronal and/or immature DA cells. We show here that the Nurr1 level and period of expression crucially affect the differentiation and maturation of Nurr1-induced DA neurons. Mature DA neurons were generated by manipulating Nurr1 expression patterns to resemble those in the developing midbrain.
URI
http://dev.biologists.org/content/139/13/2447http://hdl.handle.net/20.500.11754/49643
ISSN
0950-1991
DOI
10.1242/dev.075978
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > ETC
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