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Serum calcium and phosphorus levels in patients undergoing maintenance hemodialysis: A multicentre study in Korea

Title
Serum calcium and phosphorus levels in patients undergoing maintenance hemodialysis: A multicentre study in Korea
Author
김근호
Keywords
Calcium; Hemodialysis; Intact parathyroid hormone; Phosphorus; Secondary hyperparathyroidism
Issue Date
2014-03
Publisher
대한신장학회
Citation
Kidney Research and Clinical Practice, Vol.33 No.1 [2014], pp. 52-57(6쪽)
Abstract
Background: In many countries, nephrologists follow clinical practice guidelines for mineral bone disorders to control secondary hyperparathyroidism (SHPT) associated with abnormal serum calcium (Ca) and phosphorus (P) levels in patients undergoing maintenance hemodialysis (MHD). The Kidney Disease Outcomes Quality Initiative (KDOQI) Guidelines have long been used in Korea, and this study was undertaken to investigate the current status of serum Ca and P control in MHD patients. Methods: Data were collected from a total of 1,018 patients undergoing MHD without intercurrent illness, in 17 hemodialysis centers throughout the country. Serum levels of Ca, P, and intact parathyroid hormone (iPTH) were measured over 1 year, and the average values were retrospectively analyzed. Results: Serum levels of Ca, P, and the Ca×P product were 9.1±0.7mg/dL, 5.3±1.4mg/dL, and 48.0±13.6mg2/dL2, respectively. However, the percentages of patients with Ca, P, and Ca × P product levels within the KDOQI guideline ranges were 58.7%, 51.0%, and 70.7%, respectively. Of the 1,018 patients, 270 (26.5%) had iPTH >300pg/mL (uncontrolled SHPT), whereas 435 patients (42.7%) showed iPTH <150pg/mL. Patients with uncontrolled SHPT had significantly higher values of serum Ca, P, and Ca×P product than those with iPTH ≤300pg/mL. Conclusion: Despite the current clinical practice guidelines, SHPT seems to be inadequately controlled in many MHD patients. Uncontrolled SHPT was associated with higher levels of serum Ca, P, and Ca × P product, suggestive of the importance of SHPT management.
URI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714160/http://www.krcp-ksn.org/journal/view.html?uid=191&amp;vmd=Fullhttp://hdl.handle.net/20.500.11754/49477
ISSN
2211-9132
DOI
10.1016/j.krcp.2013.12.003
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COLLEGE OF MEDICINE[S](의과대학) > ETC
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