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dc.contributor.author채필석-
dc.date.accessioned2018-03-20T02:14:28Z-
dc.date.available2018-03-20T02:14:28Z-
dc.date.issued2014-02-
dc.identifier.citationCHEMISTRY-AN ASIAN JOURNAL, 9, 2, p632-p638en_US
dc.identifier.issn1861-4728-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/asia.201301303-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/49342-
dc.description.abstractMembrane proteins are inherently amphipathic and undergo dynamic conformational changes for proper function within native membranes. Maintaining the functional structures of these biomacromolecules in aqueous media is necessary for structural studies but difficult to achieve with currently available tools, thus necessitating the development of novel agents with favorable properties. This study introduces several new glucose-neopentyl glycol (GNG) amphiphiles and reveals some agents that display favorable behaviors for the solubilization and stabilization of a large, multi-subunit membrane protein assembly. Furthermore, a detergent structure-property relationship that could serve as a useful guideline for the design of novel amphiphiles is discussed.en_US
dc.description.sponsorshipFunding Information : National Research Foundation of Korea (NRF). Grant Numbers: 2008?0061891, 2012R1A1A1040964en_US
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.subjectamphiphilesen_US
dc.subjectmembrane proteinsen_US
dc.subjectmolecular designen_US
dc.subjectprotein solubilizationen_US
dc.subjectprotein stabilizationen_US
dc.titleImproved Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Solubilization and Stabilizationen_US
dc.typeArticleen_US
dc.relation.volume9-
dc.identifier.doi10.1002/asia.201301303-
dc.relation.page632-638-
dc.relation.journalCHEMISTRY-AN ASIAN JOURNAL-
dc.contributor.googleauthorCho, Kyung Ho-
dc.contributor.googleauthorBae, Hyoung Eun-
dc.contributor.googleauthorDas, Manabendra-
dc.contributor.googleauthorChae, Pil Seok-
dc.contributor.googleauthorGellman, Samuel H.-
dc.relation.code2014027129-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidpchae-
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