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Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats

Title
Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats
Author
전대원
Keywords
DA-9701; Gastrointestinal diseases; Visceral hypersensitivity; Colorectal distension; Phosphorylated extracellular signal-regulated kinase
Issue Date
2014-02
Publisher
EDITORIAL OFFICE GUT & LIVER, 305 LOTTE GOLD ROSE II, 890-59, DAECHI 4-DONG, GANGNAM-GU, SEOUL, 135-839, SOUTH KOREA
Citation
Gut Liver, 8, 2, 140?147.
Abstract
Background/Aims: DA-9701, a standardized extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that exhibits an analgesic effect on the abdomen. We investigated whether DA-9701 affects visceral pain induced by colorectal distension (CRD) in rats. Methods: A total of 21 rats were divided into three groups: group A (no CRD+no drug), group B (CRD+no drug), and group C (CRD+DA-9701). Expression of pain-related factors, substance P (SP), c-fos, and phosphorylated extracellular signal-regulated kinase (p-ERK) in the dorsal root ganglion (DRG) and spinal cord was determined by immunohistochemical staining and Western blotting. Results: The proportions of neurons in the DRG and spinal cord expressing SP, c-fos, and p-ERK were higher in group B than in group A. In the group C, the proportion of neurons in the DRG and spinal cord expressing p-ERK was lower than that in group B. Western blot results for p-ERK in the spinal cord indicated a higher level of expression in group B than in group A and a lower level of expression in group C than in group B. Conclusions: DA-9701 may decrease visceral pain via the downregulation of p-ERK in the DRG and spinal cord.
URI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964263/http://hdl.handle.net/20.500.11754/49326
ISSN
1976-2283; 2005-1212
DOI
10.5009/gnl.2014.8.2.140
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > ETC
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