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The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blocker

Title
The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blocker
Author
김선정
Keywords
INTERSTITIAL-CELLS; ELECTRICAL RHYTHMICITY; GASTROINTESTINAL-TRACT; TRPM7 CHANNELS; ION CHANNELS; CANCER; CAJAL; PROLIFERATION; MAGNESIUM; CALCIUM
Issue Date
2013-03
Publisher
WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Citation
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2013, 112(2), p.83-89
Abstract
Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca2+-activated Cl- conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer.
URI
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2012.00929.x/abstract;jsessionid=15F5BA7A014D957B8DA66141C772C22D.f01t03http://hdl.handle.net/20.500.11754/49162
ISSN
1742-7835
DOI
10.1111/j.1742-7843.2012.00929.x
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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