The secretory products of Trichomonas vaginalis decrease fertilizing capacity of mice sperm in vitro

Title
The secretory products of Trichomonas vaginalis decrease fertilizing capacity of mice sperm in vitro
Author
노재숙
Keywords
extracellular polymeric substances; fertilization; sperm; Trichomonas vaginalis
Issue Date
2014-12
Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
Citation
ASIAN JOURNAL OF ANDROLOGY, 권: 17, 호: 2, 페이지: 319-323
Abstract
Trichomonas vaginalis infection is one of the most prevalent sexually transmitted infections in humans and is now recognized as an important cause of infertility in men. There is little information about the effect of extracellular polymeric substances (EPS) from T. vaginalis on sperm, but previous reports do not provide a conclusive description of the functional integrity of the sperm. To investigate the impact of EPS on the fertilizing capacity of sperm, we assessed sperm motility, acrosomal status, hypo-osmotic swelling, and in vitrofertilization rate after incubating the sperm with EPS in vitrousing mice. The incubation of sperm with EPS significantly decreased sperm motility, viability, and functional integrity in a concentration and time-dependent manner. These effects on sperm quality also resulted in a decreased fertilization rate in vitro. This is the first report that demonstrates the direct negative impact of the EPS of T. vaginalis on the fertilization rate of sperm in vitro. However, further study should be performed using human sperm to determine if EPS has similar negative impact on human sperm fertilizing capacity in vitro.
URI
http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=2;spage=319;epage=323;aulast=Rohhttp://hdl.handle.net/20.500.11754/49130
ISSN
1008-682X; 1745-7262
DOI
10.4103/1008-682X.145070
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE