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CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK

Title
CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK
Author
신인철
Keywords
Breast cancer; CD24; CSC; EMT; Notch1; BREAST-CARCINOMA CELLS; P-SELECTIN; PROGNOSTIC MARKER; OVARIAN-CANCER; LIGAND; CYCLOOXYGENASE-2; PROLIFERATION; TRANSCRIPTION; ACTIVATION; EXPRESSION
Issue Date
2014-09
Publisher
ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Citation
Archives of Biochemistry and Biophysics, 2014, 558, P.120-126
Abstract
We report here that CD24 knockdown resulted in decreased expression of Notch1 in MCF-7 cells. CD24-downstream p38MAPK was shown to regulate Notch1 at the level of mRNA stability. We also found that CD24-mediated cell migration, invasion, mammosphere formation, and drug resistance was regulated by its downstream target Notch1. Together, our results indicate that CD24 may regulate the epithelial to mesenchymal transition and stemness through Notch1 signaling in breast cancer cells.
URI
http://www.sciencedirect.com/science/article/pii/S0003986114002240http://hdl.handle.net/20.500.11754/48962
ISSN
0003-9861; 1096-0384
DOI
10.1016/j.abb.2014.06.022
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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