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Development of a novel sodium fusidate-loaded triple polymer hydrogel wound dressing: Mechanical properties and effects on wound repair

Title
Development of a novel sodium fusidate-loaded triple polymer hydrogel wound dressing: Mechanical properties and effects on wound repair
Author
최한곤
Keywords
Sodium fusidate; Triple polymer hydrogel wound dressing; Permeation; Deposition; Wound repair effect; CONTROLLED DRUG-RELEASE; POLYVINYL-ALCOHOL; NANOCOMPOSITE HYDROGELS; GEL CHARACTERIZATION; HEALING EVALUATION; ALGINATE; DELIVERY; CHITOSAN; ACID; CARBOXYMETHYLCELLULOSE
Issue Date
2016-01
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 497, No. 1-2, Page. 114-122
Abstract
To develop a novel sodium fusidate-loaded triple polymer hydrogel dressing (TPHD), numerious polyvinyl alcohol-based (PVA) hydrogel dressings were prepared with various hydrophilic polymers using the freeze-thaw method, and their hydrogel dressing properties were assessed. Among the hydrophilic polymers tested, sodium alginate (SA) improved the swelling capacity the most, and polyvinyl pyrrolidone (PVP) provided the greatest improvement in bioadhesive stength and mechanical properties. Thus, PVA based-TPHDs were prepared using different ratios of PVP:SA. The effect of selected PVP:SA ratios on the swelling capacity, bioadhesive strength, mechanical properties, and drug release, permeation and deposition characteristics of sodium fusidate-loaded PVA-based TPHDs were assessed. As the ratio of PVP:SA increased in PVA-loaded TPHD, the swelling capacity, mechanical properties, drug release, permeation and deposition were improved. The TPHD containing PVA, PVP, SA and sodium fusidate at the weight ratio of 10/6/1/1 showed excellent hydrogel dressing properties, release, permeation and deposition of drug. Within 24 h, 71.8 +/- 1.3% of drug was released. It permeated 625.1 + 81.2 mu g/cm(2) through the skin and deposited of 313.8 + 24.1 mu g/cm(2) within 24 h. The results of in vivo pharmacodynamic studies showed that sodium fusidate-loaded TPHD was more effective in improving the repair process than was a commercial product. Thus, this sodium fusidate-loaded TPHD could be a novel tool in wound care. (C) 2015 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0378517315304099http://hdl.handle.net/20.500.11754/48819
ISSN
0378-5173; 1873-3476
DOI
10.1016/j.ijpharm.2015.12.007
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > ETC
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