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Microfluidic Image Cytometry (mu FIC) Assessments of Silver Nanoparticle Cytotoxicity

Title
Microfluidic Image Cytometry (mu FIC) Assessments of Silver Nanoparticle Cytotoxicity
Author
윤태현
Keywords
Microfluidic image cytometry; Microfluidic device; Cytotoxicity assessment; Ag nanoparticles; Nanotoxicity
Issue Date
2012-12
Publisher
대한화학회
Citation
Bulletin of the Korean Chemical Society, 33(12), P.4023-4027, 5P.
Abstract
Cytotoxicity assessment of silver nanoparticles (AgNPs) was performed using MTT-based microfluidic image cytometry (mu FIC). The LC50 value of HeLa cells exposed to AgNPs in the microfluidic device was estimated as 46.7 mg/L, which is similar to that estimated by MTT-based IC for cells cultured in a 96 well plate (49.9 mg/L). These results confirm that the mu FIC approach can produce cytotoxicity data that is reasonably well-matched with that of the conventional 96 well plate system with much higher efficiency. This mu FIC method provides many benefits including ease of use and low cost, and is a more rapid in vitro cell based assay for AgNPs. This may aid in speeding up data acquisition in the field of nanosafety and make a significant contribution to the quantitative understanding of nanoproperty- toxicity relationships.
URI
http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JCGMCS_2012_v33n12_4023http://hdl.handle.net/20.500.11754/48441
ISSN
1229-5949
DOI
10.5012/bkcs.2012.33.12.4023
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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