Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates
- Title
- Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates
- Author
- 김영필
- Keywords
- aptamer; cell-SELEX; bacteria; cancer cell; nanoparticle; nanomaterial
- Issue Date
- 2014-09
- Publisher
- MDPI AG
- Citation
- Sensors, 2014, 14(10), Pp 18302-18327
- Abstract
- Detection and characterization of cells using aptamers and aptamer-conjugated nanoprobes has evolved a great deal over the past few decades. This evolution has been driven by the easy selection of aptamers via in vitro cell-SELEX, permitting sensitive discrimination between target and normal cells, which includes pathogenic prokaryotic and cancerous eukaryotic cells. Additionally, when the aptamer-based strategies are used in conjunction with nanomaterials, there is the potential for cell targeting and therapeutic effects with improved specificity and sensitivity. Here we review recent advances in aptamer-based nano-conjugates and their applications for detecting cancer cells and pathogenic bacteria. The multidisciplinary research utilized in this field will play an increasingly significant role in clinical medicine and drug discovery.
- URI
- http://www.mdpi.com/1424-8220/14/10/18302http://hdl.handle.net/20.500.11754/48272
- ISSN
- 1424-8220
- DOI
- 10.3390/s141018302
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
- Files in This Item:
- sensors-14-18302 (1).pdfDownload
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