The role of leptin in gastric cancer: Clinicopathologic features and molecular mechanisms

Title
The role of leptin in gastric cancer: Clinicopathologic features and molecular mechanisms
Author
최호순
Keywords
Leptin; Leptin receptor; Gastric cancer
Issue Date
2014-04
Publisher
Elsevier Science
Citation
Biochemical and Biophysical Research Communications, 2014, 446(4), P.822-829
Abstract
Obesity is associated with certain types of cancer, including gastric cancer. However, it is still unclear whether obesity-related cytokine, leptin, is implicated in gastric cancer. Therefore, we aimed to investigate the role of leptin in gastric cancer. The expression of leptin and its receptor, Ob-R, was assessed by immunohistochemical staining and was compared in patients with gastric adenoma (n = 38), early gastric cancer (EGC) (n = 38), and advanced gastric cancer (AGC) (n = 38), as a function of their clinicopathological characteristics. Gastric cancer cell lines were studied to investigate the effects of leptin on the signal transducer and activator of transcription-3 (STAT3) and extracellular receptor kinase 1/2 (ERK1/2) signaling pathways using MTI' assays, immunoblotting, and inhibition studies. Leptin was expressed in gastric adenomas (42.1%), EGCs (47.4%), and AGCs (43.4%). Ob-R expression tended to increase from gastric adenoma (2%), through EGC (8%), to AGC (18%). Leptin induced the proliferation of gastric cancer cells by activating STAT3 and ERK1/2 and up-regulating the expression of vascular endothelial growth factor (VEGF). Blocking Ob-R with pharmacological inhibitors and by RNAi decreased both the leptin-induced activation of STAT3 and ERK1/2 and the.leptin-induced expression of VEGF. Leptin plays a role in gastric cancer by stimulating the proliferation of gastric cancer cells via activating the STAT3 and ERK1/2 pathways. (C) 2014 Elsevier Inc. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0006291X14003349http://hdl.handle.net/20.500.11754/48147
ISSN
0006-291X; 1090-2104
DOI
10.1016/j.bbrc.2014.02.072
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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