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Assessment of risk of complications in cirrhosis using portal thallium scans

Title
Assessment of risk of complications in cirrhosis using portal thallium scans
Author
전대원
Keywords
Liver cirrhosis; Portosystemic shunt; Decompensation; COUNT/SPLEEN DIAMETER RATIO; LIVER STIFFNESS MEASUREMENT; VENOUS-PRESSURE GRADIENT; CHRONIC HEPATITIS-C; ESOPHAGEAL-VARICES; TRANSIENT ELASTOGRAPHY; COMPENSATED CIRRHOSIS; NATURAL-HISTORY; HYPERTENSION; TL-201
Issue Date
2014-04
Publisher
BAISHIDENG PUBLISHING GROUP INC
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20(1), P.228-234
Abstract
AIM: To investigate the usefulness of a novel thallium scan shunt index for assessing portosystemic shuntrelated cirrhotic complications.METHODS: We enrolled 209 chronic hepatitis B-related cirrhosis patients. After rectal thallium instillation, radioactive isotope activity in the heart and liver was measured. The ratio of radiation uptake between the heart and the liver was calculated (the shunt index). This value indicates the degree of portosystemic circulation shunting. Blood tests, serum biochemistry tests, abdominal ultrasonography, gastroscopy and examination of clinical features such as the occurrence of varices, bleeding and hepatic encephalopathy were performed. Multivariate analysis was used to identify independent risk factors for complications. We compared the cumulative incidence rates of complications during the follow-up period.RESULTS: The thallium scan shunt index was significantly higher in the decompensated liver cirrhosis group than in the compensated liver cirrhosis group (0.91 +/- 0.39 vs 0.39 +/- 0.32, P < 0.001). It was also higher in the varices group, the hepatic encephalopathy group, and the variceal bleeding group than in the control group (P < 0.001). Multivariate analysis showed that the index was an independent risk factor for predicting decompensated liver cirrhosis. When the cut-off value was 0.75, the shunt index had a sensitivity of 82.6%, a specificity of 84%, a positive predictive value of 61.5%, and a negative predictive value of 94.4% in diagnosing decompensated cirrhosis. When the shunt index was greater than 0.75, there was a significant increase in the number of decompensated events.CONCLUSION: The thallium shunt index is a good predictor of cirrhosis-related complications. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
URI
https://www.wjgnet.com/1007-9327/full/v20/i1/228.htm
DOI
10.3748/wjg.v20.i1.228
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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