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dc.contributor.author송이선-
dc.date.accessioned2018-03-16T07:32:49Z-
dc.date.available2018-03-16T07:32:49Z-
dc.date.issued2014-04-
dc.identifier.citationCardiovascular Drugs and Therapy, 2014, 28(3), P.211-220en_US
dc.identifier.issn0920-3206-
dc.identifier.urihttps://link.springer.com/article/10.1007/s10557-014-6519-8-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/48081-
dc.description.abstractIn recent studies, granulocyte-colony stimulating factor (G-CSF) was shown to improve cardiac function in myocardial infarction and non-ischemic cardiomyopathies. The mechanisms of these beneficial effects of G-CSF in diabetic cardiomyopathy are not yet fully understood. Therefore, we investigated the mechanisms of action of G-CSF on diabetic cardiomyopathy in a rat model of type 2 diabetes.Seventeen-week-old OLETF (Otsuka Long Evans Tokushima Fatty) diabetic rats and LETO (Long Evans Tokushima Otuska) rats were randomized to treatment with 5 days of G-CSF (100 mu g/kg/day) or with saline. Cardiac function was evaluated by serial echocardiography performed before and 4 weeks after treatment. We measured expression of the G-CSF receptor (GCSFR) and Bcl-2, as well as the extent of apoptosis in the myocardium.G-CSF treatment significantly improved cardiac diastolic function in the serial echocardiography assessments. Expression of G-CSFR was down-regulated in the diabetic myocardium (0.03 +/- 0.12 % vs. 1 +/- 0.15 %, p < 0.05), and its expression was stimulated by G-CSF treatment (0.03 +/- 0.12 % vs. 0.42 +/- 0.06 %, p < 0.05). In addition, G-CSF treatment increased the expression of Bcl-2 in the diabetic myocardium (0.69 +/- 0.06 % vs. 0.26 +/- 0.11 %, p < 0.05), consistent with the reduced cardiomyocyte apoptosis (9.38 +/- 0.67 % vs. 17.28 +/- 2.16 %, p < 0.05).Our results suggest that G-CSF might have a cardioprotective effect in diabetic cardiomyopathy through up-regulation of G-CSFR, attenuation of apoptosis by up-regulation of Bcl-2 expression, and glucose-lowering effect. Our findings support the therapeutic potential of G-CSF in diabetic cardiomyopathy.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectApoptosisen_US
dc.subjectDiabetic cardiomyopathyen_US
dc.subjectG-CSFen_US
dc.titleGranulocyte-Colony Stimulating Factor Reduces Cardiomyocyte Apoptosis and Ameliorates Diastolic Dysfunction in Otsuka Long-Evans Tokushima Fatty Ratsen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume28-
dc.identifier.doi10.1007/s10557-014-6519-8-
dc.relation.page211-220-
dc.relation.journalCARDIOVASCULAR DRUGS AND THERAPY-
dc.contributor.googleauthorShin, J. H.-
dc.contributor.googleauthorLim, Y. H.-
dc.contributor.googleauthorSong, Y. S.-
dc.contributor.googleauthorSo, B. I.-
dc.contributor.googleauthorPark, J. Y.-
dc.contributor.googleauthorFang, C. H.-
dc.contributor.googleauthorLee, Y.-
dc.contributor.googleauthorKim, H.-
dc.contributor.googleauthorKim, K. S.-
dc.relation.code2014026873-
dc.sector.campusS-
dc.sector.daehakRESEARCH INSTITUTE[S]-
dc.sector.departmentINSTITUTE FOR THE INTERGRATION OF MEDICINE AND INNOVATIVE TECHNOLOGY-
dc.identifier.pidyisun486-
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