25 0

Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver

Title
Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver
Author
최정혜
Keywords
oxaliplatin; sinusoidal obstruction syndrome; colon cancer
Issue Date
2016-04
Publisher
SPANDIDOS PUBL LTD
Citation
ONCOLOGY LETTERS, v. 11, NO 4, Page. 2861-2864
Abstract
Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer; however, it may cause liver injury, particularly sinusoidal obstruction syndrome (SOS). Although SOS does not usually present with focal lesions on radiological images, the present study describes the case of a 22-year-old woman with oxaliplatin-induced SOS mimicking metastatic colon cancer in the liver. An abdominal computed tomography revealed a novel 1 cm, low-density lesion in segment 1 of the liver following the administration of the fourth round of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer. Since the lesion was indistinguishable from metastasis, even with detailed imaging studies, including magnetic resonance imaging and positron emission tomography-computed tomography, an isolated caudate lobectomy was planned. The cut surface of the resected liver showed a localized reddish congested lesion measuring 1.4 cm in diameter. The adjacent hepatic parenchyma also demonstrated diffuse sinusoidal congestion with a nutmeg-like appearance. Histologically, the lesion exhibited severe sinusoidal congestion with peliosis hepatis-like features. The widened sinusoidal space was outlined by markedly attenuated hepatic cords and filled with erythrocytes. The final diagnosis was oxaliplatin-induced SOS. The patient recovered completely and was relapse-free at the time of writing.
URI
https://www.spandidos-publications.com/10.3892/ol.2016.4286http://hdl.handle.net/20.500.11754/48071
ISSN
1792-1074; 1792-1082
DOI
10.3892/ol.2016.4286
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE