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Susceptibility of Escherichia coli from Community-Acquired Urinary Tract Infection to Fosfomycin, Nitrofurantoin, and Temocillin in Korea

Title
Susceptibility of Escherichia coli from Community-Acquired Urinary Tract Infection to Fosfomycin, Nitrofurantoin, and Temocillin in Korea
Author
김지은
Keywords
Community-Acquired Infections; Urinary Tract; Escherichia coli; Fosfomycin; Nitrofurantoin; Temocillin; Trimethoprim-Sulfamethoxazole combination; Ciprofloxacin; Cefepime; Minimal Inhibitory Concentration
Issue Date
2014-08
Publisher
KOREAN ACAD MEDICAL SCIENCES, 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
Citation
Journal of Korean medical science, 2014, 29(8), p1178 ~ 1182
Abstract
With increase of multi-drug resistant Escherichia coli in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this study, we evaluated in vitro susceptibility of E. coli isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 E. coli collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100% (346/346), TMO 96.8% (335/346), and NI 99.4% (344/346). Conversely, resistance rates of CIP and SMX were 22% (76/346) and 29.2% (101/349), respectively. FEP still retained an activity of 98.5%. In Korea, NI and TMO in addition to FM are a good therapeutic option for uncomplicated CA-UTI, especially for lower UTI.
URI
https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2014.29.8.1178http://hdl.handle.net/20.500.11754/47980
ISSN
1011-8934
DOI
10.3346/jkms.2014.29.8.1178
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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