Nanoemulsification of pseudo-ceramide by molecular association with mannosylerythritol lipid

Title
Nanoemulsification of pseudo-ceramide by molecular association with mannosylerythritol lipid
Author
김진웅
Keywords
Pseudo-ceramide; Crystals; Emulsions; Lipid; Molecular geometry
Issue Date
2014-06
Publisher
ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, 권: 116, 페이지: 597-602
Abstract
Ceramide molecules in water-based solutions readily attract each other to form molecular crystals, which seriously hampers to diversify their formulations. This paper describes a facile method that allows fabrication of stable ceramide emulsions through an effective molecular association with a lipid having an asymmetric molecular geometry. The lipid considered in this study is mannosylerythritol lipid (MEL). MEL is specialized in having a unique molecular structure containing sugar alcohol erythritol as a hydrophilic part and two alkyl chains with different number of carbons as hydrophobic moieties. Our particular interest has been focused on experimentally demonstrating how MEL interacts with pseudo-ceramide molecules by observing phase properties, emulsion morphology, and suspension stability. The pseudo-ceramide emulsions prepared with MEL show remarkably improved dispersion stability without either formation of molecular crystals or changes in particle sizes even after storing them for a long time. This suggests that MEL readily associates with the pseudo-ceramide due to the hydrophobic interaction, while it makes a break in the continuity of the molecular assembly of the pseudo-ceramide molecules themselves due to the geometric hindrance coming from MEL's asymmetric molecular structure. (C) 2013 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0927776513006620?via%3Dihubhttp://hdl.handle.net/20.500.11754/47676
ISSN
0927-7765; 1873-4367
DOI
10.1016/j.colsurfb.2013.10.022
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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