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PREVALENCE AND POSSIBLE CAUSES OF HYPOURICEMIA AT A TERTIARY CARE HOSPITAL IN SOUTH KOREA

Title
PREVALENCE AND POSSIBLE CAUSES OF HYPOURICEMIA AT A TERTIARY CARE HOSPITAL IN SOUTH KOREA
Author
김태환
Keywords
Hypouricemia; Uric acid
Issue Date
2014-06
Publisher
BMJ PUBLISHING GROUP, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
Citation
ANNALS OF THE RHEUMATIC DISEASES, 권: 73, p 1078-1078
Abstract
Background: Few studies of factors affecting hypouricemia have been conducted on Koreans. We aimed to investigate the prevalence and possible causes of hypouricemia in the Korean population and to compare our fi ndings to published results of other populations. Methods: We retrospectively examined serum uric acid levels from 29,672 subjects who visited outpatient clinics (n = 23,228) or were admitted to a tertiary care hospital (n = 6,444) between January 2012 and December 2012. These subjects had their uric acid values measured at least once during the one-year period. All individuals with hypouricemia (serum uric acid < 2.0 mg/dL, n = 424) were reviewed with respect to medical drug history and concomitant diseases identifi ed previously as being associated with hypouricemia. Results: The prevalence of hypouricemia among inpatients was 4.6% (299/6,444) and that among outpatients was 0.5% (125/23,228), for an overall prevalence of 1.4% (424/29,672). The possible causes associated with hypouricemia were solid or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic drugs (n = 29). The medications were allopurinol (n = 11), angiotesin II receptor blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In remaining 226 individuals, the cause of hypouricemia was not identifi ed. Overall, the prevalence and causes of hypouricemia were similar to those among the European population. Conclusions: Hypouricemia is relatively common in the Korean population. The possible causes associated with hypouricemia are related to underlying diseases and medications, and idiopathic hypouricemia such as hereditary renal hypouricemia does not appear to be rare. Although we cannot definitely conclude because fractional excretion of uric acid was not measured, genetic testing is considered necessary for patients with no known causal diseases or medications.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3273378http://hdl.handle.net/20.500.11754/47670
ISSN
0003-4967; 1468-2060
DOI
10.1136/annrheumdis-2014-eular.4189
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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