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dc.contributor.author채필석-
dc.date.accessioned2018-03-15T08:53:10Z-
dc.date.available2018-03-15T08:53:10Z-
dc.date.issued2014-06-
dc.identifier.citationNEW JOURNAL OF CHEMISTRY, 권: 38, 호: 6, 페이지: 2354-2361en_US
dc.identifier.issn1144-0546-
dc.identifier.issn1369-9261-
dc.identifier.urihttp://pubs.rsc.org/en/results?artrefjournalname=NEW%20JOURNAL%20OF%20CHEMISTRY&artrefstartpage=2354&artrefvolumeyear=2014&fcategory=journal-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/47453-
dc.description.abstractSolubilization and stabilization of membrane proteins are prerequisites for their structural study. These bio-macromolecules tend to undergo structural degradation once removed from the native membranes, necessitating the addition of detergent molecules to separate the hydrophobic portion of membrane proteins from an aqueous medium. The encapsulation of membrane proteins by detergent micelles often leads to protein denaturation and/or aggregation, presumably because of limitations in detergent properties. Here, we introduced a new TPA with a heavy atom, iodine, and found that it is superior to DDM, the most successful conventional detergent, and TPA-2, a previously described TPA with a branched diglucoside, in terms of protein solubilization and stabilization efficacy for a fragile multi-subunit superassembly. Along with these favorable properties, the presence of the heavy atom may enable us to use this agent as a useful tool for membrane protein crystallization.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2011-N).en_US
dc.language.isoenen_US
dc.publisherROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDen_US
dc.titleHeavy atom-bearing tripod amphiphiles for the membrane protein studyen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume38-
dc.identifier.doi10.1039/c4nj00033a-
dc.relation.page2354-2361-
dc.relation.journalNEW JOURNAL OF CHEMISTRY-
dc.contributor.googleauthorChae, Pil-Seok-
dc.contributor.googleauthorCho, Kyung-Ho-
dc.contributor.googleauthorBae, Hyoung-Eun-
dc.relation.code2014036698-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidpchae-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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