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dc.contributor.author안주홍-
dc.date.accessioned2018-03-15T08:27:06Z-
dc.date.available2018-03-15T08:27:06Z-
dc.date.issued2014-06-
dc.identifier.citationANIMAL CELLS AND SYSTEMS, 권: 18, 호: 3, 페이지: 172-177en_US
dc.identifier.issn1976-8354-
dc.identifier.issn2151-2485-
dc.identifier.urihttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001882903-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/47426-
dc.description.abstractBotulinum toxins (BoTXs) are potent inhibitors of neurotransmission mediated by exocytosis, cleaving synaptosomal-associated protein of 25 kDa (SNAP-25) to cause paralysis and death in human. Among them, botulinum toxin type A (BoTX/A) is both clinically and cosmetically important because of its wide application in clinical and cosmetic treatment. Therefore, development of feasible and effective model-base assay system might be very helpful to understand the effect of the toxin. In this study, we have examined the physiological effect of BoTX/A on Caenorhabditis elegans, a free-living soil nematode model system. Worms treated with BoTX/A showed defective egg-laying, yolk protein consumption, and locomotion while they were normal in developmental process. Worms' susceptibility to BoTX/A suggests potential utility for the assay of BoTX/A.en_US
dc.description.sponsorshipThis research is supported by Korean Ministry of Education (Basic Science Research Program no. 2013R1A1A2005836) and Women Scientist program [No. 2013R1A1A3A04006010] in the Basic Science Research Program through the National Research Foundation of Korea (NRF) grant funded by Korean Ministry of Science, ICT & Future Planning.en_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTD, 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDen_US
dc.subjectbotulinum toxinen_US
dc.subjectSNAP-25en_US
dc.subjectCaenorhabditis elegansen_US
dc.titlePhenotypic effect of botulinum toxin A on Caenorhabditis elegansen_US
dc.typeArticleen_US
dc.relation.volume18-
dc.identifier.doi10.1080/19768354.2014.915883-
dc.relation.page172-177-
dc.relation.journalANIMAL CELLS AND SYSTEMS-
dc.contributor.googleauthorKim, Dong-Wan-
dc.contributor.googleauthorLee, Sun-Kyung-
dc.contributor.googleauthorAhnn, Joo-hong-
dc.relation.code2014024919-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjoohong-
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COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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