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Phenotypic effect of botulinum toxin A on Caenorhabditis elegans

Title
Phenotypic effect of botulinum toxin A on Caenorhabditis elegans
Author
안주홍
Keywords
botulinum toxin; SNAP-25; Caenorhabditis elegans
Issue Date
2014-06
Publisher
TAYLOR & FRANCIS LTD, 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
Citation
ANIMAL CELLS AND SYSTEMS, 권: 18, 호: 3, 페이지: 172-177
Abstract
Botulinum toxins (BoTXs) are potent inhibitors of neurotransmission mediated by exocytosis, cleaving synaptosomal-associated protein of 25 kDa (SNAP-25) to cause paralysis and death in human. Among them, botulinum toxin type A (BoTX/A) is both clinically and cosmetically important because of its wide application in clinical and cosmetic treatment. Therefore, development of feasible and effective model-base assay system might be very helpful to understand the effect of the toxin. In this study, we have examined the physiological effect of BoTX/A on Caenorhabditis elegans, a free-living soil nematode model system. Worms treated with BoTX/A showed defective egg-laying, yolk protein consumption, and locomotion while they were normal in developmental process. Worms' susceptibility to BoTX/A suggests potential utility for the assay of BoTX/A.
URI
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001882903http://hdl.handle.net/20.500.11754/47426
ISSN
1976-8354; 2151-2485
DOI
10.1080/19768354.2014.915883
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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