52 9

Full metadata record

DC FieldValueLanguage
dc.contributor.author김태형-
dc.date.accessioned2018-03-15T08:09:04Z-
dc.date.available2018-03-15T08:09:04Z-
dc.date.issued2016-04-
dc.identifier.citationINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v. 11, Page. 775-783en_US
dc.identifier.issn1178-2005-
dc.identifier.urihttps://www.dovepress.com/impacts-of-coexisting-bronchial-asthma-on-severe-exacerbations-in-mild-peer-reviewed-article-COPD-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/47407-
dc.description.abstractBackground: Acute exacerbations are major drivers of COPD deterioration. However, limited data are available for the prevalence of severe exacerbations and impact of asthma on severe exacerbations, especially in patients with mild-to-moderate COPD. Methods: Patients with mild-to-moderate COPD (>= 40 years) were extracted from Korean National Health and Nutrition Examination Survey data (2007-2012) and were linked to the national health insurance reimbursement database to obtain medical service utilization records. Results: Of the 2,397 patients with mild-to-moderate COPD, 111 (4.6%) had severe exacerbations over the 6 years (0.012/person-year). Severe exacerbations were more frequent in the COPD patients with concomitant self-reported physician-diagnosed asthma compared with only COPD patients (P<0.001). A multiple logistic regression presented that asthma was an independent risk factor of severe exacerbations in patients with mild-to-moderate COPD regardless of adjustment for all possible confounding factors (adjusted odds ratio, 1.67; 95% confidence interval, 1.002-2.77, P=0.049). In addition, age, female, poor lung function, use of inhalers, and low EuroQoL five dimensions questionnaire index values were independently associated with severe exacerbation in patients with mild-to-moderate COPD. Conclusion: In this population-based study, the prevalence of severe exacerbations in patients with mild-to-moderate COPD was relatively low, compared with previous clinical interventional studies. Coexisting asthma significantly impacted the frequency of severe exacerbations in patients with mild-to-moderate COPD, suggesting application of an exacerbation preventive strategy in these patients.en_US
dc.description.sponsorshipThe authors would like to thank Kyungjoo Kim for the confident statistical analyses in this work. This study was supported by a grant (2014P3300300) from the Korea Centers for Disease Control and Prevention. The abstract of this paper was presented at the Asian Pacific Society of Respirology 20th Congress as an oral presentation with interim findings. The poster's abstract was published in "Poster Abstracts" in Respirology.en_US
dc.language.isoenen_US
dc.publisherINT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)en_US
dc.subjectbronchial asthmaen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectacute exacerbationen_US
dc.titleImpacts of coexisting bronchial asthma on severe exacerbations in mild-to-moderate COPD: results from a national databaseen_US
dc.typeArticleen_US
dc.relation.volume11-
dc.identifier.doi10.2147/COPD.S95954-
dc.relation.page775-783-
dc.relation.journalINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE-
dc.contributor.googleauthorLee, Hyun-
dc.contributor.googleauthorRhee, Chin Kook-
dc.contributor.googleauthorLee, Byung-Jae-
dc.contributor.googleauthorChoi, Dong-Chull-
dc.contributor.googleauthorKim, Jee-Ae-
dc.contributor.googleauthorKim, Sang Hyun-
dc.contributor.googleauthorJeong, Yoolwon-
dc.contributor.googleauthorKim, Tae-Hyung-
dc.contributor.googleauthorChon, Gyu Rak-
dc.contributor.googleauthorJung, Ki-Suck-
dc.relation.code2016002087-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.piddrterry-


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE