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dc.contributor.author최호순-
dc.date.accessioned2018-03-15T07:44:36Z-
dc.date.available2018-03-15T07:44:36Z-
dc.date.issued2014-01-
dc.identifier.citationSCANDINAVIAN JOURNAL OF GASTROENTEROLOGY; JAN 2014, 49, 1, p43-p51en_US
dc.identifier.issn0036-5521-
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.3109/00365521.2013.857712-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/47374-
dc.description.abstractBackground. Recent studies have shown that mast cells play an important role in irritable bowel syndrome (IBS). We investigated the relationship between mast cells and the gut hormones substance P and vasoactive intestinal peptide (VIP) in irritable bowel syndrome with diarrhea (IBS-D). Methods. Colonoscopic biopsies were performed on the rectal mucosa of 43 subjects (IBS-D patients: 22, healthy volunteers: 21) diagnosed according to the Rome III criteria. Mast cells, and substance P & VIP were evaluated by quantitative immunohistology and image analysis. Mast cells were counted as tryptase-positive cells in the lamina propria, and substance P and VIP levels were expressed as percentages of total areas of staining. Results. Mast cell counts were higher in IBS-D patients than healthy volunteers (9.6 +/- 3.3 vs. 5.7 +/- 2.5/high power field (HPF), p < 0.01). Substance P was also elevated (0.11 +/- 0.08% vs. 0.03 +/- 0.02 %, p < 0.01) while VIP was only high in women with IBS-D. Mast cell counts were positively correlated with levels of substance P & VIP in women but not men (women: r = 0.625, p < 0.01 for substance P and r = 0.651, p < 0.01 for VIP). However, mast cell counts were not correlated with IBS symptoms including abdominal pain. Conclusion. Mast cells are activated leading to the raised levels of substance P & VIP in IBS-D patients. However, the correlation between mast cells and levels of substance P & VIP differs according to gender.en_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.subjectirritable bowel syndromeen_US
dc.subjectmast cellen_US
dc.subjectsubstance Pen_US
dc.subjectvasoactive intestinal peptideen_US
dc.titleMast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrheaen_US
dc.typeArticleen_US
dc.relation.volume49-
dc.identifier.doi10.3109/00365521.2013.857712-
dc.relation.page43-51-
dc.relation.journalSCANDINAVIAN JOURNAL OF GASTROENTEROLOGY-
dc.contributor.googleauthorJang, Kiseok-
dc.contributor.googleauthorSohnn, Won-
dc.contributor.googleauthorLee, Oh Young-
dc.contributor.googleauthorLee, Sang Pyo-
dc.contributor.googleauthorLee, Kang Nyeong-
dc.contributor.googleauthorJun, Dae Won-
dc.contributor.googleauthorLee, Hang Lak-
dc.contributor.googleauthorYoon, Byung Chul-
dc.contributor.googleauthorChoi, Ho Soon-
dc.contributor.googleauthorSim, Jongmin-
dc.relation.code2014039148-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhschoi96-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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