Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최호순 | - |
dc.date.accessioned | 2018-03-15T07:44:36Z | - |
dc.date.available | 2018-03-15T07:44:36Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.citation | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY; JAN 2014, 49, 1, p43-p51 | en_US |
dc.identifier.issn | 0036-5521 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/abs/10.3109/00365521.2013.857712 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/47374 | - |
dc.description.abstract | Background. Recent studies have shown that mast cells play an important role in irritable bowel syndrome (IBS). We investigated the relationship between mast cells and the gut hormones substance P and vasoactive intestinal peptide (VIP) in irritable bowel syndrome with diarrhea (IBS-D). Methods. Colonoscopic biopsies were performed on the rectal mucosa of 43 subjects (IBS-D patients: 22, healthy volunteers: 21) diagnosed according to the Rome III criteria. Mast cells, and substance P & VIP were evaluated by quantitative immunohistology and image analysis. Mast cells were counted as tryptase-positive cells in the lamina propria, and substance P and VIP levels were expressed as percentages of total areas of staining. Results. Mast cell counts were higher in IBS-D patients than healthy volunteers (9.6 +/- 3.3 vs. 5.7 +/- 2.5/high power field (HPF), p < 0.01). Substance P was also elevated (0.11 +/- 0.08% vs. 0.03 +/- 0.02 %, p < 0.01) while VIP was only high in women with IBS-D. Mast cell counts were positively correlated with levels of substance P & VIP in women but not men (women: r = 0.625, p < 0.01 for substance P and r = 0.651, p < 0.01 for VIP). However, mast cell counts were not correlated with IBS symptoms including abdominal pain. Conclusion. Mast cells are activated leading to the raised levels of substance P & VIP in IBS-D patients. However, the correlation between mast cells and levels of substance P & VIP differs according to gender. | en_US |
dc.language.iso | en | en_US |
dc.publisher | INFORMA HEALTHCARE | en_US |
dc.subject | irritable bowel syndrome | en_US |
dc.subject | mast cell | en_US |
dc.subject | substance P | en_US |
dc.subject | vasoactive intestinal peptide | en_US |
dc.title | Mast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea | en_US |
dc.type | Article | en_US |
dc.relation.volume | 49 | - |
dc.identifier.doi | 10.3109/00365521.2013.857712 | - |
dc.relation.page | 43-51 | - |
dc.relation.journal | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | - |
dc.contributor.googleauthor | Jang, Kiseok | - |
dc.contributor.googleauthor | Sohnn, Won | - |
dc.contributor.googleauthor | Lee, Oh Young | - |
dc.contributor.googleauthor | Lee, Sang Pyo | - |
dc.contributor.googleauthor | Lee, Kang Nyeong | - |
dc.contributor.googleauthor | Jun, Dae Won | - |
dc.contributor.googleauthor | Lee, Hang Lak | - |
dc.contributor.googleauthor | Yoon, Byung Chul | - |
dc.contributor.googleauthor | Choi, Ho Soon | - |
dc.contributor.googleauthor | Sim, Jongmin | - |
dc.relation.code | 2014039148 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hschoi96 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.