Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 노재숙 | - |
dc.date.accessioned | 2018-03-15T07:08:33Z | - |
dc.date.available | 2018-03-15T07:08:33Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.citation | Oncology Letters, Nov 2012, 4(5), P.1033-1036, 4P. | en_US |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://www.spandidos-publications.com/10.3892/ol.2012.834 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/47318 | - |
dc.description.abstract | Kruppel-like factor 4 (KLF4) is a key transcriptional regulator of cell differentiation and proliferation and an altered expression of KLF4 has been reported in a number of human malignancies. In the present study, we investigated KLF4 expression and its role in cell proliferation in advanced epithelial ovarian cancer (FOC). We compared KLF4, Bcl-2 and Bax transcript levels in ovaries isolated from advanced EOC and normal control ovaries. In addition, the KLF4 gene was transduced into ovarian cancer cells and transcript levels of Bcl-2 and Bax and cell proliferation were analyzed by real-time RT-PCR and MTT assays, respectively. Ovarian KLF4 expression and Bcl-2/Bax ratios were downregulated in most cases of advanced EOC. In addition, KLF4 overexpression in ovarian cancer cells increased the Bcl-2/Bax ratio. However, MTT analysis indicated that the overexpression of KLF4 had no effect on the proliferation of ovarian cancer cells. The inactivation of KLF4 is frequently observed in ovarian cancers and a reduced expression of KLF4 in the ovarian cancers may lead to a reduction in the Bcl-2/Bax ratio. The latter has a role in predicting cancer grade, although its exact role in ovarian carcinogenesis requires clarification. | en_US |
dc.description.sponsorship | We thank Professor Hyun Kook (Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Korea) for the gift of the pCMV3-FLAG-KLF4 plasmid construct. This study was supported by a Korea Research Foundation Grant funded by the Korean Government (KRF 2009-0074679 and 2009-0065769). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.subject | KLF4 | en_US |
dc.subject | Bcl-2 | en_US |
dc.subject | Bax | en_US |
dc.subject | epithelial ovarian cancer | en_US |
dc.title | Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer | en_US |
dc.title.alternative | Bax ratio in advanced epithelial ovarian cancer | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 4 | - |
dc.identifier.doi | 10.3892/ol.2012.834 | - |
dc.relation.page | 1033-1036 | - |
dc.relation.journal | ONCOLOGY LETTERS | - |
dc.contributor.googleauthor | Yoon, O. | - |
dc.contributor.googleauthor | Roh, J. | - |
dc.relation.code | 2012233197 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | rohjaesook | - |
dc.identifier.researcherID | 56248416400 | - |
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