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dc.contributor.author노재숙-
dc.date.accessioned2018-03-15T07:08:33Z-
dc.date.available2018-03-15T07:08:33Z-
dc.date.issued2012-11-
dc.identifier.citationOncology Letters, Nov 2012, 4(5), P.1033-1036, 4P.en_US
dc.identifier.issn1792-1074-
dc.identifier.urihttps://www.spandidos-publications.com/10.3892/ol.2012.834-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/47318-
dc.description.abstractKruppel-like factor 4 (KLF4) is a key transcriptional regulator of cell differentiation and proliferation and an altered expression of KLF4 has been reported in a number of human malignancies. In the present study, we investigated KLF4 expression and its role in cell proliferation in advanced epithelial ovarian cancer (FOC). We compared KLF4, Bcl-2 and Bax transcript levels in ovaries isolated from advanced EOC and normal control ovaries. In addition, the KLF4 gene was transduced into ovarian cancer cells and transcript levels of Bcl-2 and Bax and cell proliferation were analyzed by real-time RT-PCR and MTT assays, respectively. Ovarian KLF4 expression and Bcl-2/Bax ratios were downregulated in most cases of advanced EOC. In addition, KLF4 overexpression in ovarian cancer cells increased the Bcl-2/Bax ratio. However, MTT analysis indicated that the overexpression of KLF4 had no effect on the proliferation of ovarian cancer cells. The inactivation of KLF4 is frequently observed in ovarian cancers and a reduced expression of KLF4 in the ovarian cancers may lead to a reduction in the Bcl-2/Bax ratio. The latter has a role in predicting cancer grade, although its exact role in ovarian carcinogenesis requires clarification.en_US
dc.description.sponsorshipWe thank Professor Hyun Kook (Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Korea) for the gift of the pCMV3-FLAG-KLF4 plasmid construct. This study was supported by a Korea Research Foundation Grant funded by the Korean Government (KRF 2009-0074679 and 2009-0065769).en_US
dc.language.isoenen_US
dc.publisherSPANDIDOS PUBL LTDen_US
dc.subjectKLF4en_US
dc.subjectBcl-2en_US
dc.subjectBaxen_US
dc.subjectepithelial ovarian canceren_US
dc.titleDownregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian canceren_US
dc.title.alternativeBax ratio in advanced epithelial ovarian canceren_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume4-
dc.identifier.doi10.3892/ol.2012.834-
dc.relation.page1033-1036-
dc.relation.journalONCOLOGY LETTERS-
dc.contributor.googleauthorYoon, O.-
dc.contributor.googleauthorRoh, J.-
dc.relation.code2012233197-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidrohjaesook-
dc.identifier.researcherID56248416400-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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