Effect of multispecies probiotics on irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial

Title
Effect of multispecies probiotics on irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial
Author
최호순
Keywords
irritable bowel syndrome; microbiot; probiotics
Issue Date
2014-01
Publisher
WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Citation
Journal of Gastroenterology and Hepatology, Volume 29, Issue 1, Pages 52?59
Abstract
Background and AimThe efficacy of treatment with multispecies probiotics on irritable bowel syndrome (IBS) symptoms and the alterations of gut microbiota in patients who have taken probiotics were investigated.MethodsThis randomized, double-blind, placebo-controlled trial involved 49 IBS patients (probiotics: 25, placebo: 24) diagnosed according to the Rome III criteria. Patients were randomly assigned to two groups: either to receive multispecies probiotics (a mixture of Bifidobacterium longum, B.?bifidum, B.?lactis, Lactobacillus acidophilus, L.?rhamnosus, and Streptococcus thermophilus) twice a day for 4 weeks or to receive a placebo twice a day for 4 weeks. The primary efficacy end-point was the proportion of participants whose IBS symptoms were substantially relieved at week 4. Secondary end-points were the intensity of abdominal pain/discomfort, bloating, stool frequency/consistency, alterations in fecal microflora over the 4 weeks. Fecal microflora were analyzed in 34 patients (probiotics: 17, placebo: 17) by quantitative real-time polymerase chain reaction assays.ResultsThe proportion of patients whose IBS symptoms were substantially relieved at week 4 was significantly higher in the probiotics group than in the placebo group: 68.0% (17/25) versus 37.5% (9/24) (P?<?0.05). Secondary end-points such as improvement in abdominal pain/discomfort and bloating occurred in the probiotics group but not in the placebo group. Fecal analysis revealed that B.?lactis, L.?rhamnosus, and S.?thermophilus had increased significantly in the probiotics group after 4 weeks and that B.?lactis had increased in the placebo group.ConclusionsMultispecies probiotics are effective in IBS patients and induce the alterations in the composition of intestinal microbiota.
URI
http://onlinelibrary.wiley.com/doi/10.1111/jgh.12322/fullhttp://hdl.handle.net/20.500.11754/47310
ISSN
0815-9319; 1440-1746
DOI
10.1111/jgh.12322
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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