Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최종훈 | - |
dc.date.accessioned | 2018-03-15T05:56:22Z | - |
dc.date.available | 2018-03-15T05:56:22Z | - |
dc.date.issued | 2014-05 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF NANOMEDICINE, 권: 9, 페이지: 127-139 | en_US |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://www.dovepress.com/a-glimpse-into-the-interactions-of-cells-in-a-microenvironment-the-mod-peer-reviewed-article-IJN | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/47161 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell-cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell-cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions. | en_US |
dc.description.sponsorship | We thank Professor Sun W Song from Inha University Hospital, Incheon, South Korea, for kindly providing bone marrow-derived MSCs. We also thank the editorial board of the IEEE International Conference on Nano/Molecular Medicine and Engineering (Bangkok, Thailand) for providing us an opportunity to present our preliminary findings as a conference proceeding paper.21 This work was supported by the Korea Institute of Science and Technology (KIST Institutional Project #2E24680 and KIST Convergence Technology Program #2V03320) and the National Research Foundation (NRF) grant funded by the Korean government (MSIP) (No. 2008-0061891). | en_US |
dc.language.iso | en | en_US |
dc.publisher | DOVE MEDICAL PRESS LTD, PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND | en_US |
dc.subject | mesenchymal stem cell | en_US |
dc.subject | T cell | en_US |
dc.subject | microwell array | en_US |
dc.title | A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.2147/IJN.S50767 | - |
dc.relation.page | 127-139 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.contributor.googleauthor | Choi, Jonghoon | - |
dc.contributor.googleauthor | Hwang, Mintai P. | - |
dc.contributor.googleauthor | Lee, Jong-Wook | - |
dc.contributor.googleauthor | Lee, Kwan Hyi | - |
dc.relation.code | 2014031644 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | jonghchoi | - |
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