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dc.contributor.author최종훈-
dc.date.accessioned2018-03-15T05:56:22Z-
dc.date.available2018-03-15T05:56:22Z-
dc.date.issued2014-05-
dc.identifier.citationINTERNATIONAL JOURNAL OF NANOMEDICINE, 권: 9, 페이지: 127-139en_US
dc.identifier.issn1178-2013-
dc.identifier.urihttps://www.dovepress.com/a-glimpse-into-the-interactions-of-cells-in-a-microenvironment-the-mod-peer-reviewed-article-IJN-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/47161-
dc.description.abstractMesenchymal stem cells (MSCs) have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell-cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell-cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions.en_US
dc.description.sponsorshipWe thank Professor Sun W Song from Inha University Hospital, Incheon, South Korea, for kindly providing bone marrow-derived MSCs. We also thank the editorial board of the IEEE International Conference on Nano/Molecular Medicine and Engineering (Bangkok, Thailand) for providing us an opportunity to present our preliminary findings as a conference proceeding paper.21 This work was supported by the Korea Institute of Science and Technology (KIST Institutional Project #2E24680 and KIST Convergence Technology Program #2V03320) and the National Research Foundation (NRF) grant funded by the Korean government (MSIP) (No. 2008-0061891).en_US
dc.language.isoenen_US
dc.publisherDOVE MEDICAL PRESS LTD, PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALANDen_US
dc.subjectmesenchymal stem cellen_US
dc.subjectT cellen_US
dc.subjectmicrowell arrayen_US
dc.titleA glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cellsen_US
dc.typeArticleen_US
dc.identifier.doi10.2147/IJN.S50767-
dc.relation.page127-139-
dc.relation.journalINTERNATIONAL JOURNAL OF NANOMEDICINE-
dc.contributor.googleauthorChoi, Jonghoon-
dc.contributor.googleauthorHwang, Mintai P.-
dc.contributor.googleauthorLee, Jong-Wook-
dc.contributor.googleauthorLee, Kwan Hyi-
dc.relation.code2014031644-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidjonghchoi-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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