A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells

Title
A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells
Author
최종훈
Keywords
mesenchymal stem cell; T cell; microwell array
Issue Date
2014-05
Publisher
DOVE MEDICAL PRESS LTD, PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
Citation
INTERNATIONAL JOURNAL OF NANOMEDICINE, 권: 9, 페이지: 127-139
Abstract
Mesenchymal stem cells (MSCs) have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell-cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell-cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions.
URI
https://www.dovepress.com/a-glimpse-into-the-interactions-of-cells-in-a-microenvironment-the-mod-peer-reviewed-article-IJNhttp://hdl.handle.net/20.500.11754/47161
ISSN
1178-2013
DOI
10.2147/IJN.S50767
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE