Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane
- Title
- Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane
- Author
- 소홍윤
- Keywords
- CONTROLLED-RELEASE; MICROPUMP; FLOW
- Issue Date
- 2014-08
- Publisher
- AMER INST PHYSICS
- Citation
- BIOMICROFLUIDICS, 2014, 8(4), p1-8
- Abstract
- We report a refillable and valveless drug delivery device actuated by an external magnetic field for on- demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 1861.5 mu g per actuation was achieved under a 500mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.
- URI
- https://aip.scitation.org/doi/10.1063/1.4893912http://hdl.handle.net/20.500.11754/46926
- ISSN
- 1932-1058
- DOI
- 10.1063/1.4893912
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > MECHANICAL ENGINEERING(기계공학부) > Articles
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