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dc.contributor.author최재훈-
dc.date.accessioned2018-03-15T01:02:52Z-
dc.date.available2018-03-15T01:02:52Z-
dc.date.issued2014-07-
dc.identifier.citationNature Communications, 6, P.1-13en_US
dc.identifier.issn2041-1723-
dc.identifier.urihttps://www.nature.com/articles/ncomms7076-
dc.description.abstractHyperlipidemia is a well-recognized risk factor for atherosclerosis and can be regulated by adipokines. Expression of the adipokine resistin-like molecule alpha (Retnla) is regulated by food intake; whether Retnla has a role in the pathogenesis of hyperlipidemia and atherosclerosis is unknown. Here we report that Retnla has a cholesterol-lowering effect and protects against atherosclerosis in low-density lipoprotein receptor-deficient mice. On a high-fat diet, Retnla deficiency promotes hypercholesterolaemia and atherosclerosis, whereas Retnla overexpression reverses these effects and improves the serum lipoprotein profile, with decreased cholesterol in the very low-density lipoprotein fraction concomitant with reduced serum apolipoprotein B levels. We show that Retnla upregulates cholesterol-7-α-hydroxylase, a key hepatic enzyme in the cholesterol catabolic pathway, through induction of its transcriptional activator liver receptor homologue-1, leading to increased excretion of cholesterol in the form of bile acids. These findings define Retnla as a novel therapeutic target for treating hypercholesterolaemia and atherosclerosis.en_US
dc.description.sponsorshipThis work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2012R1A3A2026454).en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectRESISTIN-LIKE-MOLECULEen_US
dc.subjectBILE-ACID SYNTHESISen_US
dc.subjectINDUCED INSULIN-RESISTANCEen_US
dc.subjectE-DEFICIENT MICEen_US
dc.subjectADIPOSE-TISSUEen_US
dc.subjectTYPE-2 INFLAMMATIONen_US
dc.subjectPROMOTES ATHEROSCLEROSISen_US
dc.subjectCARDIOVASCULAR-DISEASEen_US
dc.subjectTRANSGENIC EXPRESSIONen_US
dc.subjectNUCLEAR RECEPTORSen_US
dc.titleThe adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic miceen_US
dc.typeArticleen_US
dc.relation.volume5-
dc.identifier.doi10.1038/ncomms7076-
dc.relation.page4410-4410-
dc.relation.journalNATURE COMMUNICATIONS-
dc.contributor.googleauthorLee, Mi-Ran-
dc.contributor.googleauthorLim, Chae-ji-
dc.contributor.googleauthorLee, You-Han-
dc.contributor.googleauthorPark, Jong-Gil-
dc.contributor.googleauthorSonn, Seong Keun-
dc.contributor.googleauthorLee, Mi-Ni-
dc.contributor.googleauthorJung, In-Hyuk-
dc.contributor.googleauthorJeong, Se-Jin-
dc.contributor.googleauthorJeon, Sejin-
dc.contributor.googleauthorChoi, Jae-Hoon-
dc.relation.code2014036437-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjchoi75-
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COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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