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Enhanced transdermal delivery by using electrostatically interactive chitosan nanocapsules

Title
Enhanced transdermal delivery by using electrostatically interactive chitosan nanocapsules
Author
김진웅
Keywords
Transdermal delivery; Chitosan nanocapsules; Stratum corneum; Surface charge; Electrostatic interaction
Issue Date
2012-04
Publisher
Springer Science + Business Media
Citation
Colloid and Polymer Science, 2012, 290(6), P.553-559
Abstract
This paper describes a useful means of noninvasively enhancing transdermal delivery efficiency. For this, chitosan nanocapsules with positive surface charges were fabricated by using the in situ precipitation method. These nanocapsules cannot only have an ability to encapsulate the drug molecule (this study used riboflavin 5'-monophosphate), but also electrotatically interact with the stratum corneum layer. To demonstrate this, fluorescence-labeled polymer nanoparticles with different particle sizes as well as surface charges were topically applied onto the skin and their distribution was directly imaged. This demonstration experiment allowed us to figure out that once the nanocapsules were provided with positive surface charges, they readily deposited into the stratum corneum layer due to the electrostatic interaction. Further quantitative characterization of the penetrating amount of riboflavin 5'-monophosphate by using the Frantz diffusion cell method showed that our chitosan nanocapsule system effectively improved transdermal delivery efficiency.
URI
https://link.springer.com/article/10.1007%2Fs00396-011-2580-zhttp://hdl.handle.net/20.500.11754/46865
ISSN
0303-402X
DOI
10.1007/s00396-011-2580-z
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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