53 8

Association of Serum Ferritin and Kidney Function with Age-Related Macular Degeneration in the General Population

Title
Association of Serum Ferritin and Kidney Function with Age-Related Macular Degeneration in the General Population
Author
박준성
Keywords
C-REACTIVE PROTEIN; METABOLIC SYNDROME; RISK-FACTORS; KOREAN POPULATION; DISEASE; IRON; NEURODEGENERATION; PATHOGENESIS; HEALTH; CELLS
Issue Date
2016-04
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v. 11, NO 4, Page. 1-11
Abstract
Ferritin is considered to be a marker of the body's iron stores and has a potential relationship with the systemic manifestations of inflammatory reactions. Data on the association between increased levels of serum ferritin and ocular problems are limited, particularly in relation to age-related macular degeneration (AMD#. Serum ferritin levels, as a possible clinical parameter for predicting AMD, were analyzed in anthropometric, biochemical, and ophthalmologic data from a nation-wide, population-based, case-control study #KNHNES IV and V#. All native Koreans aged ˃= 20 years and who had no medical illness were eligible to participate. Among them, 2.9% had AMD, and its prevalence was found to increase in the higher ferritin quintile groups #P-trend ˂ 0.0001#. In multiple linear regression analysis, serum ferritin level was closely related to conventional risk factors for AMD. Comparison of early AMD with a control group showed that serum ferritin levels were closely associated with AMD #OR = 1.004, 95% CI = 1.002-1.006#, and further adjustment for age, gender, serum iron, and kidney function did not reduce this association #OR = 1.003, 95% CI = 1.001-1.006). Furthermore, the relationship between ferritin quintile and early AMD was dose-dependent. Thus, an increased level of serum ferritin in a healthy person may be a useful indicator of neurodegenerative change in the macula. A large population-based prospective clinical study is needed to confirm these findings.
URI
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153624#ackhttp://hdl.handle.net/20.500.11754/46739
ISSN
1932-6203
DOI
10.1371/journal.pone.0153624
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
Association of Serum Ferritin and Kidney Function with Age-Related Macular Degeneration in the General Population.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE