Follow-up Testing of Interferon-Gamma Release Assays Are Useful in Ankylosing Spondylitis Patients Receiving Anti-Tumor Necrosis Factor Alpha for Latent Tuberculosis Infection
- Title
- Follow-up Testing of Interferon-Gamma Release Assays Are Useful in Ankylosing Spondylitis Patients Receiving Anti-Tumor Necrosis Factor Alpha for Latent Tuberculosis Infection
- Author
- 김태환
- Keywords
- Ankylosing Spondylitis; Interferon-Gamma Release Assay; Anti-Tumor Necrosis Factor; Latent Tuberculosis Infection
- Issue Date
- 2014-08
- Publisher
- KOREAN ACAD MEDICAL SCIENCES, 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
- Citation
- Journal of Korean medical science, 2014, 29(8), p1090 ~ 1093
- Abstract
- We evaluated the utility of follow-up interferon-gamma release assays (IGRAs) for the diagnosis of reactivation of latent tuberculosis infection (LTBI) or new tuberculosis in ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor alpha (anti-TNF alpha). The study participants (n = 127) had a negative IGRA screening before receiving anti-TNF alpha and were evaluated by follow-up IGRA. We retrospectively examined data of the subjects according to age, gender, tuberculosis prophylaxis, concomitant medications, IGRA conversion and anti-TNF alpha, including type and treatment duration. The median duration of anti-TNF alpha was 21.5 months, and the median age was 35.3 yr. Of the 127 patients, IGRA conversion was found in 10 patients (7.9%). There was no significant variation between IGRA conversion rate and any risk factors except for age. IGRA conversion rate was not significantly different between AS and rheumatoid arthritis (P = 0.12). IGRA conversion was observed in AS patients receiving anti-TNF alpha in Korea. A follow-up IGRA test can be helpful for identifying LTBI or new tuberculosis in AS patients receiving anti-TNF alpha.
- URI
- https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2014.29.8.1090http://hdl.handle.net/20.500.11754/46642
- ISSN
- 1011-8934
- DOI
- 10.3346/jkms.2014.29.8.1090
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
- jkms-29-1090.pdfDownload
- Export
- RIS (EndNote)
- XLS (Excel)
- XML