Exercise Training suppresses vascular fibrosis in aging obesity induced rats

Abstract

Shin Young Kim and Jin Lee. Exercise Training suppresses vascular fibrosis in aging obesity induced rats. JENB., Vol. 18, No.2, pp.175-180, 2014 [Purpose] The aim of this study was to investigate the effects of exercise training (ET) on vascular fibrosisin aging model rats with diet-induced obesity. [Methods] Twenty-four male Sprague-Dawley rats were divided into 3 groups:Aging control (A-C), A-C with high fat diet (AHF), AHF with ET (AHF + ET). Aging was induced by D-galactose (D-gal) andobesity was induced by HFD (60% fat) for 9 weeks. The experimental rats performed swimming (60 min/day, 5 days/week) for8 weeks. All rat aorta samples were harvested for RT-PCR and morphologic analyses. [Results] The exercise training significantlydecreased levels of AT-1, TGF-SS and Coll-1 gene expression compared to AHF group. The AHF + ET group showed a reducedcollagen accumulation in the aorta media compared to AHF group. [Conclusion] These results suggest that ET could protect theaging obesity aorta against down-regulation of fibrotic factors (AT-1, TGF-SS and Coll-1 gene) and fibrosis by inhibition of collagenaccumulation in the aorta media. [Keyword] Exercise training, vascular fibrosis