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dc.contributor.authorKlaus Heese-
dc.date.accessioned2018-03-14T00:17:42Z-
dc.date.available2018-03-14T00:17:42Z-
dc.date.issued2013-06-
dc.identifier.citationMolecular Neurobiology, June 2013, 47(3), pp.1103-1111en_US
dc.identifier.issn0893-7648-
dc.identifier.urihttps://link.springer.com/article/10.1007/s12035-013-8410-1-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/46383-
dc.description.abstractAlzheimer’s disease (AD) is a complex brain disorder of the limbic system and association cortices. The disease is characterized by the production and deposition of the amyloid β-peptide (Aβ) in the brain, and the neuropathological mechanisms involved must be deciphered to gain further insights into the fundamental aspects of the protein biology responsible for the development and progression of this disease. Aβ is generated by the intramembranous cleavage of the β-amyloid precursor protein, which is mediated by the proteases β- and γ-secretase. Accumulating evidence suggests the importance of the coupling of this cleavage mechanism to G protein signaling. Heterotrimeric G proteins play pivotal roles as molecular switches in signal transduction pathways mediated by G protein-coupled receptors (GPCRs). Extracellular stimuli activate these receptors, which in turn catalyze guanosine triphosphate?guanosine diphosphate exchange on the G protein α-subunit. The activation?deactivation cycles of G proteins underlie their crucial functions as molecular switches for a vast array of biological responses. The novel transcription regulator protein p60 transcription regulator protein and its related GPCR signaling pathways have recently been described as potential targets for the development of alternative strategies for inhibiting the early signaling mechanisms involved in neurodegenerative diseases such as AD.en_US
dc.description.sponsorshipThis study was supported by the Hanyang University, Seoul, Republic of Korea.en_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.subjectALSen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectAPPen_US
dc.subjectbHLHB9en_US
dc.subjectCpG island hypermethylationen_US
dc.subjectGASPen_US
dc.subjectGPCRen_US
dc.subjectGPRASPen_US
dc.subjectG proteinen_US
dc.subjectHuntington’s diseaseen_US
dc.subjectp60TRPen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectPIPSen_US
dc.subjectSchizophreniaen_US
dc.subjectTauen_US
dc.titleG Proteins, p60TRP, and Neurodegenerative Diseasesen_US
dc.typeArticleen_US
dc.relation.volume47-
dc.identifier.doi10.1007/s12035-013-8410-1-
dc.relation.page1103-1111-
dc.relation.journalMOLECULAR NEUROBIOLOGY-
dc.contributor.googleauthorHeese, K.-
dc.relation.code2013011346-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S]-
dc.identifier.pidklaus-
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