Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이민형 | - |
dc.date.accessioned | 2018-03-13T05:02:52Z | - |
dc.date.available | 2018-03-13T05:02:52Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.citation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Feb 2011, 11(2), P.1799-1802, 4P. | en_US |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.issn | 1533-4899 | - |
dc.identifier.uri | http://www.ingentaconnect.com/content/asp/jnn/2011/00000011/00000002/art00178;jsessionid=6kdiumqrqae24.x-ic-live-01 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45913 | - |
dc.description.abstract | In this study, dexamethasone was conjugated to PAMAM dendrimer (generation 0) and its gene transfection efficiency was investigated. To make a liposomal solution for gene delivery, DOPE was used as a fusogenic helper lipid. In gel retardation assay, PAMAM-dexamethasone conjugate (PAM-Dex)/DOPE liposome/DNA complex was completely retarded at 8:1 N/P (nitrogen/phosphate) ratio. The physicochemical characteristics are studied by measuring the average size distribution and zeta-potential values of the complexes. In vitro transfection assay showed that the PAM-Dex/DOPE liposome/DNA complex displayed higher gene delivery efficiency compared to PAMAM/DNA complex. In addition, PAM-Dex/DOPE liposome showed the lowest toxicity compared to PAMAM, PEI 25 kD and Lipofectamine. These results indicate that PAM-Dex/DOPE liposome has a potential to be used as an efficient gene carrier for gene therapy. | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | en_US |
dc.subject | Dendrimer | en_US |
dc.subject | Dexamethasone | en_US |
dc.subject | Cationic Liposome | en_US |
dc.subject | Gene Transfection | en_US |
dc.title | Preparation of Dexamethasone-Based Cationic Liposome and Its Application to Gene Delivery In Vitro | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.1166/jnn.2011.3407 | - |
dc.relation.page | 1799-1802 | - |
dc.relation.journal | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.contributor.googleauthor | Kim, Tae-Hun | - |
dc.contributor.googleauthor | Yu, Gwang Sig | - |
dc.contributor.googleauthor | Choi, Hye | - |
dc.contributor.googleauthor | Shim, Young Jung | - |
dc.contributor.googleauthor | Choi, Joon Sig | - |
dc.contributor.googleauthor | Lee, Minhyung | - |
dc.relation.code | 2011214452 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | minhyung | - |
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