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dc.contributor.author이민형-
dc.date.accessioned2018-03-13T05:02:52Z-
dc.date.available2018-03-13T05:02:52Z-
dc.date.issued2011-02-
dc.identifier.citationJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Feb 2011, 11(2), P.1799-1802, 4P.en_US
dc.identifier.issn1533-4880-
dc.identifier.issn1533-4899-
dc.identifier.urihttp://www.ingentaconnect.com/content/asp/jnn/2011/00000011/00000002/art00178;jsessionid=6kdiumqrqae24.x-ic-live-01-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/45913-
dc.description.abstractIn this study, dexamethasone was conjugated to PAMAM dendrimer (generation 0) and its gene transfection efficiency was investigated. To make a liposomal solution for gene delivery, DOPE was used as a fusogenic helper lipid. In gel retardation assay, PAMAM-dexamethasone conjugate (PAM-Dex)/DOPE liposome/DNA complex was completely retarded at 8:1 N/P (nitrogen/phosphate) ratio. The physicochemical characteristics are studied by measuring the average size distribution and zeta-potential values of the complexes. In vitro transfection assay showed that the PAM-Dex/DOPE liposome/DNA complex displayed higher gene delivery efficiency compared to PAMAM/DNA complex. In addition, PAM-Dex/DOPE liposome showed the lowest toxicity compared to PAMAM, PEI 25 kD and Lipofectamine. These results indicate that PAM-Dex/DOPE liposome has a potential to be used as an efficient gene carrier for gene therapy.en_US
dc.language.isoenen_US
dc.publisherAMER SCIENTIFIC PUBLISHERSen_US
dc.subjectDendrimeren_US
dc.subjectDexamethasoneen_US
dc.subjectCationic Liposomeen_US
dc.subjectGene Transfectionen_US
dc.titlePreparation of Dexamethasone-Based Cationic Liposome and Its Application to Gene Delivery In Vitroen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume11-
dc.identifier.doi10.1166/jnn.2011.3407-
dc.relation.page1799-1802-
dc.relation.journalJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY-
dc.contributor.googleauthorKim, Tae-Hun-
dc.contributor.googleauthorYu, Gwang Sig-
dc.contributor.googleauthorChoi, Hye-
dc.contributor.googleauthorShim, Young Jung-
dc.contributor.googleauthorChoi, Joon Sig-
dc.contributor.googleauthorLee, Minhyung-
dc.relation.code2011214452-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidminhyung-
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COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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