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dc.contributor.author민경환-
dc.date.accessioned2018-03-13T02:42:22Z-
dc.date.available2018-03-13T02:42:22Z-
dc.date.issued2013-12-
dc.identifier.citationAnnals of Surgical Oncology, Volume 20, Supplement 3, pp 433?442en_US
dc.identifier.issn1068-9265-
dc.identifier.issn1534-4681-
dc.identifier.urihttps://link.springer.com/article/10.1245/s10434-012-2734-3-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/45796-
dc.description.abstractBackgroundMatrix metalloproteinase 11 (MMP-11) is a matrix degrading enzyme known to be involved in the remodeling of extracellular matrix proteins. This enzyme recently has been reported to play a key role in tumor progression and results in poor clinical outcomes for several different types of tumors.MethodsA total of 192 patients diagnosed with invasive ductal carcinoma between 2000 and 2005 were included in this study. MMP-11 expression in tumors and stromal fibroblast-like cells was analyzed by immunohistochemical staining on a tissue microarray. Subsequently, evaluation of the associations between MMP-11 expression and clinicopathological characteristics was performed.ResultsMMP-11 expression of stromal fibroblast-like cells was correlated with prognostic factors, including tumor size, metastasis, histological grade, central tumor fibrosis, p53 expression, and luminal A subtype and was linked to therapeutic markers, such as ER and HER2 (all p < 0.05). There was a significant relationship between worse overall survival and MMP-11 expression in both tumors and stromal fibroblast-like cells (all p < 0.05). In multivariate analysis, MMP-11 expression of stromal fibroblast-like cells was still significantly associated with poor prognosis (p = 0.043).ConclusionsMMP-11 expression was significantly related to clinicopathological parameters, which may be essential to the prediction of disease outcome in patients with invasive ductal carcinoma of the breast.en_US
dc.description.sponsorshipThe authors are grateful to Dr. Min Kim at the Department of Ophthalmology, Yonsei Medical Center, Dr. Hack Lyoung Kim at the Department of Internal Medicine, Seoul National University Hospital, and English teacher Joung Woo Hong for editing this manuscript.en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.subjectEstrogen Receptoren_US
dc.subjectTrastuzumaben_US
dc.subjectHistological Gradeen_US
dc.subjectAxillary Lymph Node Dissectionen_US
dc.subjectInvasive Ductal Carcinomaen_US
dc.titleDiagnostic and prognostic relevance of MMP-11 expression in the stroma adjacent to invasive ductal carcinoma of the breasten_US
dc.typeArticleen_US
dc.identifier.doi10.1245/s10434-012-2734-3-
dc.relation.journalANNALS OF SURGICAL ONCOLOGY-
dc.contributor.googleauthorMin, Kyueng-Whan-
dc.contributor.googleauthorKim, Dong-Hoon-
dc.contributor.googleauthorDo, Sung-Im-
dc.contributor.googleauthorPyo, Jung-Soo-
dc.contributor.googleauthorKim, Kyungeun-
dc.contributor.googleauthorChae, Seoung Wan-
dc.contributor.googleauthorSohn, Jin HeeOh, Young-HaKim, Hong JooChoi, Seon Hyeong-
dc.relation.code2013008899-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkyueng-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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