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Nutritional regulation of stem and progenitor cells in Drosophila

Title
Nutritional regulation of stem and progenitor cells in Drosophila
Author
심지원
Keywords
Drosophila; Insulin; Dilp; Germline stem cell; Intestinal stem cell; Hematopoietic progenitor cell; Neural stem cell; Amino acid sensing; Nutritional control
Issue Date
2013-12
Publisher
COMPANY OF BIOLOGISTS LTD
Citation
DEVELOPMENT, 140, 23, p4647-p4656
Abstract
Stem cells and their progenitors are maintained within a microenvironment, termed the niche, through local cell-cell communication. Systemic signals originating outside the niche also affect stem cell and progenitor behavior. This review summarizes studies that pertain to nutritional effects on stem and progenitor cell maintenance and proliferation in Drosophila. Multiple tissue types are discussed that utilize the insulin-related signaling pathway to convey nutritional information either directly to these progenitors or via other cell types within the niche. The concept of systemic control of these cell types is not limited to Drosophila and may be functional in vertebrate systems, including mammals.
URI
http://dev.biologists.org/content/140/23/4647.shorthttp://hdl.handle.net/20.500.11754/45770
ISSN
0950-1991
DOI
10.1242/dev.079087
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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