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dc.contributor.author최재훈-
dc.date.accessioned2018-03-12T05:46:06Z-
dc.date.available2018-03-12T05:46:06Z-
dc.date.issued2013-06-
dc.identifier.citationPlos one, 2013, 8(6), P.e66970en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066970-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/45389-
dc.description.abstractRecently, it has been demonstrated that high cholesterol diet induced hypercholesterolemia and vascular lipid oxidation and accumulation in zebrafish larvae, suggesting that zebrafish is a new promising atherosclerosis model in addition to mouse models. However, up to date, there was no report regarding inflammatory cytokine expression during the lipid accumulation in zebrafish larva and adult fish. In this study, we first demonstrated the expression levels of IL-1 beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae, and found that although HCD induced vascular lipid accumulation, the cytokine expressions in the larvae were not changed by HCD. Furthermore, there was no significant difference in leukocyte accumulation in vessels between control and HCD fed group. But prolonged HCD induced IL-1 beta expression in spleen and liver compared to those of control zebrafish, and produced very early stage of fatty streak lesion in dorsal aorta of 19 week HCD-fed zebrafish. These results indicate that HCD induced hypercholesterolemia and atherosclerotic changes in zebrafish are very early stage, and suggest the necessity of the generation of mutant zebrafish having a disruption in a lipid metabolism-related gene leading to severe hypercholesterolemia and advanced atherosclerosis.en_US
dc.description.sponsorshipThis work was funded by the Ministry of Education, Science and Technology, Korea (2011-0005843) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, South Korea (2011-0013669). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.language.isoenen_US
dc.publisherNational Institutes of Healthen_US
dc.subjectAnimalsen_US
dc.subjectBlood Vesselsen_US
dc.subjectdrug effectsen_US
dc.subjectimmunologyen_US
dc.subjectmetabolismen_US
dc.subjectCholesterol, adverse effectsen_US
dc.subjectDieten_US
dc.subjectHigh-Faten_US
dc.subjectFemaleen_US
dc.subjectGene Expression Regulationen_US
dc.subjectHypercholesterolemiaen_US
dc.subjectetiology, geneticsen_US
dc.subjectImmunityen_US
dc.subjectInnateen_US
dc.subjectInterleukin-1betaen_US
dc.subjectLarva, Leukocytesen_US
dc.subjectMaleen_US
dc.subjectMiceen_US
dc.subjectTime Factorsen_US
dc.subjectTumor Necrosis Factor-alphaen_US
dc.subjectZebrafishen_US
dc.subjectZebrafish Proteinsen_US
dc.titleHigh Cholesterol Diet Induces IL-1 beta Expression in Adult but Not Larval Zebrafishen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume8-
dc.identifier.doi10.1371/journal.pone.0066970-
dc.relation.page1-8-
dc.relation.journalPLOS ONE-
dc.contributor.googleauthorYoon, Yina-
dc.contributor.googleauthorYoon, Jihye-
dc.contributor.googleauthorJang, Man-Young-
dc.contributor.googleauthorNa, Yirang-
dc.contributor.googleauthorKo, Youngho-
dc.contributor.googleauthorChoi, Jae-Hoon-
dc.contributor.googleauthorSeok, Seung Hyeok-
dc.relation.code2013007124-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjchoi75-


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